US 11,714,273 B1
System and method for microscope high-speed auto-focusing including an imaged subject based on a corrected contrast distribution
Shiou-jyh Ja, Portland, OR (US)
Assigned to Araceli Biosciences Inc., Tigard, OR (US)
Filed by Araceli Biosciences Inc., Tigard, OR (US)
Filed on Jun. 23, 2022, as Appl. No. 17/808,491.
Int. Cl. G02B 21/24 (2006.01); G02B 21/36 (2006.01)
CPC G02B 21/244 (2013.01) [G02B 21/367 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method for microscope auto-focusing, comprising:
acquiring a plurality of contrast samples of an imaged subject;
modeling a contrast distribution based on the plurality of contrast samples;
acquiring an additional contrast sample based on the contrast distribution;
modeling a corrected contrast distribution based on the additional contrast sample and the plurality of contrast samples; and
focusing the imaged subject based on the corrected contrast distribution.