CPC G01N 33/6803 (2013.01) [B81B 1/008 (2013.01); G01N 1/36 (2013.01); G01N 23/046 (2013.01)] | 13 Claims |
1. A method for determining a three dimensional (3D) structure of a biomolecule, said method comprising:
preparing (S1) an amorphous silica matrix that encapsulates said biomolecule;
preparing (S2) a needle specimen comprising said amorphous silica matrix that encapsulates said biomolecule; and
performing (S3) atom probe tomography analysis of said needle specimen to determine said 3D structure of said biomolecule,
wherein preparing (S1) said amorphous silica matrix comprises encapsulating said biomolecule via a sol-gel process that uses an organic precursor to silica and/or an inorganic precursor to silica.
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