CPC C07D 213/81 (2013.01) | 17 Claims |
1. A process for preparing a compound of Formula (8)
or a salt thereof, comprising:
contacting a compound of Formula (I) or a salt thereof,
wherein:
R1 is C1-4 alkyl, CH2Cl, phenyl, or benzyl, in which each of phenyl and benzyl may be independently substituted with one, two or three substituents selected from methyl, methoxy, nitro and halogen; and
R2 is C1-4 alkyl,
with a hydrolyzing agent,
wherein the compound of Formula (I) or a salt thereof is prepared by a process comprising:
a) contacting a compound of Formula (5) or a salt thereof,
with a compound of Formula (II) or a salt thereof in the presence of a base,
wherein R1 is C1-4 alkyl, CH2Cl, phenyl, or benzyl, in which each of phenyl and benzyl may be independently substituted with one, two or three substituents selected from methyl, methoxy, nitro and halogen; and
b) contacting a product formed in step a) with a compound of Formula (III) or a salt thereof in the presence of a base,
wherein R2 is C1-4 alkyl; and
c) washing the compound of Formula (I) from step b) with a solvent comprising water and a base,
to provide the compound of Formula (I) or a salt thereof,
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