US 11,713,292 B2
Treatment of cataplexy
Moise A. Khayrallah, Morrisville, NC (US); Gary Bream, Cary, NC (US); and Stephen E. Butts, Holly Springs, NC (US)
Assigned to Axsome Malta Ltd, Qormi (MT); and SK Biopharmaceuticals Co., Ltd., Seongnam-si (KR)
Filed by Axsome Malta Ltd., Qorm (MT); and SK Biopharmaceuticals Co., Ltd., Seongnam-si (KR)
Filed on Jul. 23, 2021, as Appl. No. 17/383,707.
Application 17/383,707 is a continuation of application No. 16/359,446, filed on Mar. 20, 2019, granted, now 11,072,579, issued on Jul. 27, 2021.
Application 16/359,446 is a continuation of application No. 15/419,133, filed on Jan. 30, 2017, granted, now 10,259,780, issued on Apr. 16, 2019.
Application 15/419,133 is a continuation of application No. 15/149,478, filed on May 9, 2016, granted, now 9,585,863, issued on Mar. 7, 2017.
Application 15/149,478 is a continuation of application No. 14/205,423, filed on Mar. 12, 2014, granted, now 9,359,290, issued on Jun. 7, 2016.
Claims priority of provisional application 61/778,998, filed on Mar. 13, 2013.
Prior Publication US 2022/0017457 A1, Jan. 20, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/27 (2006.01); A61K 31/325 (2006.01); C07C 271/02 (2006.01); C07C 271/00 (2006.01); A61K 9/00 (2006.01); A61K 45/06 (2006.01); A61K 9/20 (2006.01)
CPC C07C 271/02 (2013.01) [A61K 9/0053 (2013.01); A61K 9/20 (2013.01); A61K 31/27 (2013.01); A61K 31/325 (2013.01); A61K 45/06 (2013.01); C07C 271/00 (2013.01)] 18 Claims
 
1. A method of treating cataplexy in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I):

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt or ester thereof;
wherein R is a member selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, halogen selected from F, Cl, Br and I, alkoxy containing 1 to 3 carbon atoms, nitro, hydroxy, trifluoromethyl, and thioalkoxy containing 1 to 3 carbon atoms;
x is; and
R1 and R2 are hydrogen.