CPC A61M 5/14 (2013.01) [A61F 2/2481 (2013.01); A61M 5/14276 (2013.01); A61F 2002/2484 (2013.01); A61F 2230/0067 (2013.01); A61F 2240/001 (2013.01); A61F 2250/0068 (2013.01); A61L 31/005 (2013.01); A61L 31/146 (2013.01); A61L 31/148 (2013.01); A61L 31/16 (2013.01); A61L 2300/60 (2013.01); A61L 2300/64 (2013.01); A61L 2430/20 (2013.01); A61M 5/1723 (2013.01); A61M 2205/04 (2013.01); A61M 2205/05 (2013.01); A61M 2210/122 (2013.01); A61M 2210/125 (2013.01)] | 21 Claims |
1. A device for administration of a substance to a surface of a heart of a patient, comprising:
a heart-shaped self-expanding unit, comprising
a frame structure for at least partially encircling a circumference of the heart, the frame structure comprising
a flexible ring structure comprising a single wire formed to follow a periodic, alternating course, wherein the flexible ring structure defines a circumference of an upper edge of the heart-shaped self-expanding unit, and
a recess in the flexible ring structure dropping beneath the upper edge of the heart-shaped self-expanding unit toward an apex of the heart and defining a break in the circumference of the upper edge of the heart-shaped self-expanding unit, wherein
the recess defines an open region extending from below the upper edge of the heart-shaped self-expanding unit and through the upper edge of the heart-shaped self-expanding unit, wherein the open region corresponds to an anatomical structure of the heart,
a sleeve coupled to the frame structure and sized to fit about the apex and at least a portion of ventricles of the heart, wherein the sleeve comprises an internal contour that corresponds to a natural outer contour of the heart of the patient, and
a plurality of expandable chambers configured to selectively apply pressure to the heart via hydraulic or pneumatic actuation, wherein
the heart-shaped self-expanding unit is configured for introduction into a pericardium of the patient in a collapsed state, wherein
the heart-shaped self-expanding unit automatically transforms from the collapsed state to an expanded state upon release in the pericardium of the patient; and
a substance carrier for delivering the substance, wherein the substance carrier is coupled to the heart-shaped self-expanding unit.
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4. A heart-shaped self-expanding unit, comprising:
a flexible ring structure for at least partially encircling a circumference of a heart, the flexible ring structure defining a circumference of an upper edge of the heart-shaped self-expanding unit, the flexible ring structure comprising
a single wire formed to follow a periodic, alternating course at least partially encircling the circumference of the heart, and
a recess in the flexible ring structure dropping beneath the upper edge of the heart-shaped self-expanding unit toward an apex of the heart and defining a break in the circumference of the upper edge of the heart-shaped self-expanding unit defined by the flexible ring structure, wherein
the recess defines an open region extending from below the upper edge of the heart-shaped self-expanding unit and through the upper edge of the heart-shaped self-expanding unit, wherein
the open region corresponds to an anatomical structure of the heart;
a sleeve coupled to the flexible ring structure and sized to fit about the apex and at least a portion of ventricles of the heart, wherein the sleeve comprises an internal contour that corresponds to a natural outer contour of the heart of a patient; and
a plurality of expandable chambers configured to selectively apply pressure to the heart via hydraulic or pneumatic actuation;
wherein the heart-shaped self-expanding unit is configured for introduction into a pericardium of the patient in a collapsed state; and
wherein the heart-shaped self-expanding unit automatically transforms from the collapsed state to an expanded state upon release in the pericardium of the patient.
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