US 11,712,511 B2
Implantable device for the locationally accurate delivery and administration of substances into the pericardium or onto the surface of the heart
Stephen Manuel Wildhirt, Munich (DE); Andreas Maier, Grafing bei Muenchen (DE); Kei Wieland Muller, Munich (DE); and Bjorn Hofmann, Oberding (DE)
Assigned to AdjuCor GmbH, Munich (DE)
Filed by AdjuCor GmbH, Munich (DE)
Filed on Dec. 10, 2019, as Appl. No. 16/709,716.
Application 16/709,716 is a continuation of application No. 14/794,459, filed on Jul. 8, 2015, abandoned.
Claims priority of application No. 102015212699.4 (DE), filed on Jul. 7, 2015.
Prior Publication US 2020/0375742 A1, Dec. 3, 2020
Int. Cl. A61M 5/14 (2006.01); A61F 2/24 (2006.01); A61M 5/142 (2006.01); A61L 31/14 (2006.01); A61L 31/16 (2006.01); A61L 31/00 (2006.01); A61M 5/172 (2006.01)
CPC A61M 5/14 (2013.01) [A61F 2/2481 (2013.01); A61M 5/14276 (2013.01); A61F 2002/2484 (2013.01); A61F 2230/0067 (2013.01); A61F 2240/001 (2013.01); A61F 2250/0068 (2013.01); A61L 31/005 (2013.01); A61L 31/146 (2013.01); A61L 31/148 (2013.01); A61L 31/16 (2013.01); A61L 2300/60 (2013.01); A61L 2300/64 (2013.01); A61L 2430/20 (2013.01); A61M 5/1723 (2013.01); A61M 2205/04 (2013.01); A61M 2205/05 (2013.01); A61M 2210/122 (2013.01); A61M 2210/125 (2013.01)] 21 Claims
OG exemplary drawing
 
1. A device for administration of a substance to a surface of a heart of a patient, comprising:
a heart-shaped self-expanding unit, comprising
a frame structure for at least partially encircling a circumference of the heart, the frame structure comprising
a flexible ring structure comprising a single wire formed to follow a periodic, alternating course, wherein the flexible ring structure defines a circumference of an upper edge of the heart-shaped self-expanding unit, and
a recess in the flexible ring structure dropping beneath the upper edge of the heart-shaped self-expanding unit toward an apex of the heart and defining a break in the circumference of the upper edge of the heart-shaped self-expanding unit, wherein
the recess defines an open region extending from below the upper edge of the heart-shaped self-expanding unit and through the upper edge of the heart-shaped self-expanding unit, wherein the open region corresponds to an anatomical structure of the heart,
a sleeve coupled to the frame structure and sized to fit about the apex and at least a portion of ventricles of the heart, wherein the sleeve comprises an internal contour that corresponds to a natural outer contour of the heart of the patient, and
a plurality of expandable chambers configured to selectively apply pressure to the heart via hydraulic or pneumatic actuation, wherein
the heart-shaped self-expanding unit is configured for introduction into a pericardium of the patient in a collapsed state, wherein
the heart-shaped self-expanding unit automatically transforms from the collapsed state to an expanded state upon release in the pericardium of the patient; and
a substance carrier for delivering the substance, wherein the substance carrier is coupled to the heart-shaped self-expanding unit.
 
4. A heart-shaped self-expanding unit, comprising:
a flexible ring structure for at least partially encircling a circumference of a heart, the flexible ring structure defining a circumference of an upper edge of the heart-shaped self-expanding unit, the flexible ring structure comprising
a single wire formed to follow a periodic, alternating course at least partially encircling the circumference of the heart, and
a recess in the flexible ring structure dropping beneath the upper edge of the heart-shaped self-expanding unit toward an apex of the heart and defining a break in the circumference of the upper edge of the heart-shaped self-expanding unit defined by the flexible ring structure, wherein
the recess defines an open region extending from below the upper edge of the heart-shaped self-expanding unit and through the upper edge of the heart-shaped self-expanding unit, wherein
the open region corresponds to an anatomical structure of the heart;
a sleeve coupled to the flexible ring structure and sized to fit about the apex and at least a portion of ventricles of the heart, wherein the sleeve comprises an internal contour that corresponds to a natural outer contour of the heart of a patient; and
a plurality of expandable chambers configured to selectively apply pressure to the heart via hydraulic or pneumatic actuation;
wherein the heart-shaped self-expanding unit is configured for introduction into a pericardium of the patient in a collapsed state; and
wherein the heart-shaped self-expanding unit automatically transforms from the collapsed state to an expanded state upon release in the pericardium of the patient.