US 11,712,482 B2
Near infrared fluorescent dyes, formulations and related methods
Samuel Achilefu, St. Louis, MO (US); Rui Tang, St. Louis, MO (US); Duanwen Shen, St. Louis, MO (US); Avik Som, St. Louis, MO (US); Baogang Xu, St. Louis, MO (US); Gail Sudlow, St. Louis, MO (US); Christopher Egbulefu, St. Louis, MO (US); Partha Karmakar, St. Louis, MO (US); and Kexian Liang, St. Louis, MO (US)
Assigned to WASHINGTON UNIVERSITY, St. Louis, MO (US)
Filed by Washington University, St. Louis, MO (US)
Filed on Dec. 11, 2020, as Appl. No. 17/119,305.
Claims priority of provisional application 62/976,702, filed on Feb. 14, 2020.
Claims priority of provisional application 62/947,974, filed on Dec. 13, 2019.
Prior Publication US 2021/0177993 A1, Jun. 17, 2021
Int. Cl. A61K 49/00 (2006.01); C09B 69/10 (2006.01); A61K 9/00 (2006.01); A61K 47/42 (2017.01); A61P 35/00 (2006.01); A61K 9/19 (2006.01)
CPC A61K 49/0034 (2013.01) [A61K 9/0019 (2013.01); A61K 9/19 (2013.01); A61K 47/42 (2013.01); A61K 49/0056 (2013.01); A61K 49/0089 (2013.01); A61P 35/00 (2018.01); C09B 69/105 (2013.01)] 22 Claims
 
1. A lyophilized product comprising
a dye-conjugate chosen from cypate-Cyclo(Cys-Gly-Arg-Asp-Ser-Pro-Cys)-Lys-OH (LS301), cypate-Cyclo(Cys-Gly-Arg-Asp-Ser-Pro-Cys)-Tyr-OH (LS838) or pharmaceutically acceptable salts thereof, wherein each amino acid residue is independently in a D or L configuration, and
albumin, wherein the dye-conjugate and the albumin are in a 1:50 (w/w) ratio.