CPC A61K 9/4808 (2013.01) [A61B 5/14503 (2013.01); A61B 5/14539 (2013.01); A61B 10/02 (2013.01); A61J 3/07 (2013.01); A61K 9/0002 (2013.01); A61K 9/0012 (2013.01); A61K 9/0021 (2013.01); A61K 9/0065 (2013.01); A61K 9/0092 (2013.01); A61K 9/4866 (2013.01); A61K 38/28 (2013.01); A61M 5/14276 (2013.01); A61M 5/158 (2013.01); A61M 5/2033 (2013.01); A61M 5/329 (2013.01); A61M 5/3295 (2013.01); A61M 31/002 (2013.01); A61M 37/0015 (2013.01); A61N 1/325 (2013.01); A61N 1/36007 (2013.01); A61B 10/0233 (2013.01); A61B 2010/0208 (2013.01); A61M 2005/14284 (2013.01); A61M 2005/1585 (2013.01); A61M 2037/0023 (2013.01); A61M 2037/0053 (2013.01); A61M 2205/0238 (2013.01); A61M 2205/21 (2013.01); A61M 2210/106 (2013.01); A61M 2210/1053 (2013.01); A61N 1/0509 (2013.01)] | 21 Claims |
1. An article, comprising:
an outer shell;
a spring at least partially encapsulated within the outer shell;
a support material associated with the spring such that the support material maintains at least a portion of the spring under at least 5% compressive strain under ambient conditions; and
a tissue interfacing component operably linked to the spring,
wherein the article comprises a monostatic body due to a center of mass of the article and/or a shape of the article, such that the article has a single stable resting position.
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16. A method, comprising:
administering, to a subject, a self-righting article, the self-righting article comprising:
an outer shell;
a spring at least partially encapsulated with the outer shell;
a support material associated with the spring such that the support material maintains at least a portion of the spring under at least 10% compressive strain under ambient conditions; and
a tissue interfacing component associated with the spring,
wherein the self-righting article comprises a monostatic body due to a center of mass of the self-righting article and/or a shape of the self-righting article, such that the self-righting article obtains a single stable resting position.
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17. A method for puncturing a tissue located internally of a subject, comprising:
administering, to a subject, a self-righting article, the self-righting article comprising:
an outer shell;
a spring at least partially encapsulated by the outer shell;
a support material associated with the spring such that the support material maintains at least a portion of the spring under at least 10% compressive strain under ambient conditions; and
a tissue interfacing component associated with the spring;
wherein at least a portion of the support material is degraded such that the spring extends and/or the tissue interfacing component penetrates a tissue located internal to the subject, and
wherein the self-righting article comprises a monostatic body due to a center of mass of the self-righting article and/or a shape of the self-righting article, such that the self-righting article has a single stable resting position.
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20. An article, comprising:
a tissue interfacing component and a spring associated with the tissue interfacing component, the spring maintained in an at least partially compressed state by a support material under at least 5% compressive strain,
wherein the spring is configured to release at least 10% of a stored compressive energy of the spring within 10 minutes of exposing the support material to a fluid,
wherein the article comprises a monostatic body due to a center of mass of the article and/or a shape of the article, such that the article has a single stable resting position.
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