US 11,712,421 B2
Self-actuating articles
Carlo Giovanni Traverso, Newton, MA (US); Alex G. Abramson, St. Louis, MO (US); Ester Caffarel Salvador, Cambridge, MA (US); Niclas Roxhed, Cambridge, MA (US); Minsoo Khang, Boston, MA (US); Taylor Bensel, Walpole, MA (US); and Robert S. Langer, Newton, MA (US)
Assigned to Massachusetts Institute of Technology, Cambridge, MA (US); and The Brigham and Women's Hospital, Inc., Boston, MA (US)
Appl. No. 16/614,177
Filed by Massachusetts Institute of Technology, Cambridge, MA (US); and The Brigham and Women's Hospital, Inc., Boston, MA (US)
PCT Filed May 17, 2018, PCT No. PCT/US2018/033187
§ 371(c)(1), (2) Date Nov. 15, 2019,
PCT Pub. No. WO2018/213579, PCT Pub. Date Nov. 22, 2018.
Claims priority of provisional application 62/507,665, filed on May 17, 2017.
Claims priority of provisional application 62/507,647, filed on May 17, 2017.
Claims priority of provisional application 62/507,653, filed on May 17, 2017.
Prior Publication US 2022/0257855 A1, Aug. 18, 2022
Int. Cl. A61K 9/48 (2006.01); A61J 3/07 (2006.01); A61K 9/00 (2006.01); A61B 5/145 (2006.01); A61B 10/02 (2006.01); A61M 5/142 (2006.01); A61M 37/00 (2006.01); A61N 1/32 (2006.01); A61N 1/36 (2006.01); A61M 5/20 (2006.01); A61M 5/32 (2006.01); A61M 31/00 (2006.01); A61K 38/28 (2006.01); A61M 5/158 (2006.01); A61N 1/05 (2006.01)
CPC A61K 9/4808 (2013.01) [A61B 5/14503 (2013.01); A61B 5/14539 (2013.01); A61B 10/02 (2013.01); A61J 3/07 (2013.01); A61K 9/0002 (2013.01); A61K 9/0012 (2013.01); A61K 9/0021 (2013.01); A61K 9/0065 (2013.01); A61K 9/0092 (2013.01); A61K 9/4866 (2013.01); A61K 38/28 (2013.01); A61M 5/14276 (2013.01); A61M 5/158 (2013.01); A61M 5/2033 (2013.01); A61M 5/329 (2013.01); A61M 5/3295 (2013.01); A61M 31/002 (2013.01); A61M 37/0015 (2013.01); A61N 1/325 (2013.01); A61N 1/36007 (2013.01); A61B 10/0233 (2013.01); A61B 2010/0208 (2013.01); A61M 2005/14284 (2013.01); A61M 2005/1585 (2013.01); A61M 2037/0023 (2013.01); A61M 2037/0053 (2013.01); A61M 2205/0238 (2013.01); A61M 2205/21 (2013.01); A61M 2210/106 (2013.01); A61M 2210/1053 (2013.01); A61N 1/0509 (2013.01)] 21 Claims
OG exemplary drawing
 
1. An article, comprising:
an outer shell;
a spring at least partially encapsulated within the outer shell;
a support material associated with the spring such that the support material maintains at least a portion of the spring under at least 5% compressive strain under ambient conditions; and
a tissue interfacing component operably linked to the spring,
wherein the article comprises a monostatic body due to a center of mass of the article and/or a shape of the article, such that the article has a single stable resting position.
 
16. A method, comprising:
administering, to a subject, a self-righting article, the self-righting article comprising:
an outer shell;
a spring at least partially encapsulated with the outer shell;
a support material associated with the spring such that the support material maintains at least a portion of the spring under at least 10% compressive strain under ambient conditions; and
a tissue interfacing component associated with the spring,
wherein the self-righting article comprises a monostatic body due to a center of mass of the self-righting article and/or a shape of the self-righting article, such that the self-righting article obtains a single stable resting position.
 
17. A method for puncturing a tissue located internally of a subject, comprising:
administering, to a subject, a self-righting article, the self-righting article comprising:
an outer shell;
a spring at least partially encapsulated by the outer shell;
a support material associated with the spring such that the support material maintains at least a portion of the spring under at least 10% compressive strain under ambient conditions; and
a tissue interfacing component associated with the spring;
wherein at least a portion of the support material is degraded such that the spring extends and/or the tissue interfacing component penetrates a tissue located internal to the subject, and
wherein the self-righting article comprises a monostatic body due to a center of mass of the self-righting article and/or a shape of the self-righting article, such that the self-righting article has a single stable resting position.
 
20. An article, comprising:
a tissue interfacing component and a spring associated with the tissue interfacing component, the spring maintained in an at least partially compressed state by a support material under at least 5% compressive strain,
wherein the spring is configured to release at least 10% of a stored compressive energy of the spring within 10 minutes of exposing the support material to a fluid,
wherein the article comprises a monostatic body due to a center of mass of the article and/or a shape of the article, such that the article has a single stable resting position.