US 11,712,417 B2
Fast dispersing suspending composition, method of preparation and application thereof
Enxian Lu, East Brunswick, NJ (US); Peng Hou, Shanghai (CN); Longlong Feng, Shanghai (CN); and Long Wang, Shanghai (CN)
Assigned to AUSON PHARMACEUTICALS INC., Bridgewater, NJ (US)
Filed by Auson Pharmaceuticals, Inc., Bridgewater, NJ (US)
Filed on Jun. 8, 2022, as Appl. No. 17/805,967.
Application 17/805,967 is a continuation in part of application No. PCT/CN2022/076541, filed on Feb. 17, 2022.
Claims priority of application No. 202111569644.9 (CN), filed on Dec. 21, 2021.
Prior Publication US 2023/0190646 A1, Jun. 22, 2023
Int. Cl. A61K 9/00 (2006.01); A61K 47/26 (2006.01); A61K 47/36 (2006.01); A61K 47/02 (2006.01)
CPC A61K 9/0095 (2013.01) [A61K 47/02 (2013.01); A61K 47/26 (2013.01); A61K 47/36 (2013.01)] 18 Claims
 
1. A method of dispersing a solid dosage form in water to form a suspension, comprising:
(a) adding the solid dosage form comprising an active ingredient to water; and
(b) adding a powder suspending composition to the water;
wherein the solid dosage form of step (a) and the powder suspending composition of step (b) are separately added to the water;
wherein the suspending composition is free from the active ingredient and comprises a suspending agent, a diluent, and a glidant;
wherein the suspending agent ranges from 0.5% to 10% (w/w) in the composition and is selected from the group consisting of xanthan gum, carbomer, croscarmellose sodium, and any combination thereof;
wherein the diluent ranges from 86% to 96% (w/w) in the composition and is selected from the group consisting of maltitol, xylitol, sucrose, sorbitol, and any combination thereof;
wherein the glidant ranges from 0.1% to 5% (w/w) in the composition and is selected from the group consisting of silicon dioxide, talc, and any combination thereof;
wherein the suspending agent, the diluent, the glidant and their respective amounts are selected so that the suspending composition under a testing condition meets the following: the composition dissolves in water in less than 60 seconds to form a solution, and the solution exhibits a viscosity of higher than 30 cps; and
wherein under the testing condition the suspending composition is added alone into 20 ml of water to form a mixture consisting of the composition and water, and the mixture is shaken with a wrist action shaker at 120 rpm at a shaking angle 10°.