US 11,712,193 B2
Reliable seizure detection with a parallelizable, multi-trajectory estimate of lyapunov exponents
Ashfaque Shafique, Chandler, AZ (US); David Treiman, Phoenix, AZ (US); and Konstantinos Tsakalis, Chandler, AZ (US)
Assigned to Arizona Board of Regents on behalf of Arizona State University, Scottsdale, AZ (US); and Dignity Health, San Francisco, CA (US)
Appl. No. 16/326,259
Filed by Arizona Board of Regents on behalf of Arizona State University, Scottsdale, AZ (US); and DIGNITY HEALTH, San Francisco, CA (US)
PCT Filed Aug. 17, 2017, PCT No. PCT/US2017/047303
§ 371(c)(1), (2) Date Feb. 18, 2019,
PCT Pub. No. WO2018/035299, PCT Pub. Date Feb. 22, 2018.
Claims priority of provisional application 62/376,330, filed on Aug. 17, 2016.
Prior Publication US 2019/0209072 A1, Jul. 11, 2019
Int. Cl. A61B 5/291 (2021.01); A61B 5/316 (2021.01); A61B 5/369 (2021.01); A61B 5/00 (2006.01)
CPC A61B 5/4094 (2013.01) [A61B 5/291 (2021.01); A61B 5/316 (2021.01); A61B 5/369 (2021.01); A61B 5/6803 (2013.01); A61B 5/7235 (2013.01); A61B 5/7282 (2013.01); A61B 5/742 (2013.01)] 8 Claims
OG exemplary drawing
 
1. A system for detecting a seizure associated with a subject, the system comprising:
a cap with a plurality of electroencephalogram electrodes configured to connect to a subject;
an electroencephalogram machine connected to the cap that records electroencephalogram data using the electroencephalogram electrodes;
a display device; and
a computer system in communication with the electroencephalogram recording machine, the computer system being configured to:
receive, from the electroencephalogram machine, electroencephalogram data;
identify a set of Kantz algorithm parameters by iteratively evaluating possible values for each parameter using historical electroencephalogram data;
process the electroencephalogram data associated with a subject using the set of Kantz algorithm parameters to identify a series of Lyapunov exponents;
determine the electroencephalogram data is associated with an epileptic seizure based upon the series of Lyapunov exponents; and
cause the display device to display a representation of the series of Lyapunov exponents.