US 11,708,571 B2
Production of 2-keto-3-deoxy-d-gluconic acid in filamentous fungi
Molly Krebs, Naperville, IL (US); Chris Phillips, Naperville, IL (US); and Fernando Valle, Naperville, IL (US)
Assigned to BP Corporation North America Inc., Houston, TX (US)
Appl. No. 17/56,146
Filed by BP CORPORATION NORTH AMERICA INC., Houston, TX (US)
PCT Filed May 14, 2019, PCT No. PCT/US2019/032232
§ 371(c)(1), (2) Date Nov. 17, 2020,
PCT Pub. No. WO2019/222226, PCT Pub. Date Nov. 21, 2019.
Claims priority of provisional application 62/672,719, filed on May 17, 2018.
Prior Publication US 2021/0214706 A1, Jul. 15, 2021
Int. Cl. C12N 9/88 (2006.01); C12P 7/42 (2006.01); C12N 1/14 (2006.01)
CPC C12N 9/88 (2013.01) [C12N 1/14 (2013.01); C12P 7/42 (2013.01); C12Y 401/02014 (2013.01)] 15 Claims
OG exemplary drawing
 
1. A genetically modified filamentous fungus having reduced 2-Keto-3-Deoxy-Gluconate (KDG) aldolase enzyme activity as compared to the KDG aldolase enzyme activity in a wild type counterpart of said filamentous fungus, wherein said filamentous fungus is an Aspergillus niger strain.