US 11,708,348 B2
Protease inhibitors for treatment of coronavirus infections
Arnab K. Chatterjee, San Diego, CA (US); Jian Jeffrey Chen, San Diego, CA (US); Elshan Nakath, La Jolla, CA (US); Alireza Rahimi, La Jolla, CA (US); Anil Kumar Gupta, San Diego, CA (US); Gennadii Grabovyi, La Jolla, CA (US); Katy Wilson, La Jolla, CA (US); Sourav Ghorai, La Jolla, CA (US); Armen Nazarian, La Jolla, CA (US); James Pedroarena, La Jolla, CA (US); Wrickban Mazumdar, La Jolla, CA (US); Frank Weiss, La Jolla, CA (US); Lirui Song, San Diego, CA (US); Malina A. Bakowski, La Jolla, CA (US); Laura Riva, San Diego, CA (US); Karen Wolff, Encinitas, CA (US); Case W. McNamara, San Marcos, CA (US); Thomas F. Rogers, Del Mar, CA (US); Jacqueline Malvin, San Diego, CA (US); Shuangwei Li, San Diego, CA (US); Sean Joseph, San Diego, CA (US); Ashley Woods, San Diego, CA (US); Yuyin Liu, San Diego, CA (US); and Neechi Okwor, Del Mar, CA (US)
Assigned to The Scripps Research Institute, La Jolla, CA (US)
Filed by The Scripps Research Institute, La Jolla, CA (US)
Filed on Jun. 10, 2022, as Appl. No. 17/837,814.
Claims priority of provisional application 63/266,234, filed on Dec. 30, 2021.
Claims priority of provisional application 63/209,862, filed on Jun. 11, 2021.
Prior Publication US 2023/0024012 A1, Jan. 26, 2023
Int. Cl. C07D 401/12 (2006.01); A61K 38/55 (2006.01); C07D 207/267 (2006.01); C07D 211/76 (2006.01); C07D 403/12 (2006.01); C07D 405/10 (2006.01); C07D 405/12 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 471/04 (2006.01); C07D 493/04 (2006.01)
CPC C07D 401/12 (2013.01) [A61K 38/55 (2013.01); C07D 207/267 (2013.01); C07D 211/76 (2013.01); C07D 403/12 (2013.01); C07D 405/10 (2013.01); C07D 405/12 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 471/04 (2013.01); C07D 493/04 (2013.01)] 4 Claims
 
1. A compound, which is (S)-5-((R)-2-hydroxy-4-methylpentanoyl)-N—((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide, or a pharmaceutically acceptable salt thereof.