CPC C07D 249/12 (2013.01) [A61K 9/10 (2013.01); A61K 31/18 (2013.01); A61P 3/00 (2018.01); A61P 25/28 (2018.01); C07D 243/10 (2013.01)] | 24 Claims |
1. A pharmaceutical composition comprising (a) at least one compound of Formula (I),
wherein
R1, R2, and R3 are each independently hydrogen, hydroxy, halogen, optionally substituted C1-4 alkyl, optionally substituted C1-4 alkoxy, —CN, —C(O)Rx, —C(O)ORx, —S(O)2Rx, or —NRyRz;
Rx, Ry, and Rz are each independently H or optionally substituted C1-4alkyl, or Ry and Rz taken together with the nitrogen to which they are attached form an optionally substituted monocyclic heterocycloalkyl ring;
or a pharmaceutically acceptable salt thereof, and
(b) a pharmaceutically acceptable excipient,
wherein the pharmaceutically acceptable excipient is selected from the group consisting of a polymeric agent, carboxymethyl cellulose (CMC), hydroxypropyl cellulose (HPC), hydroxyethyl cellulose (HEC), hydroxypropylmethyl cellulose (HPMC), gelatin, gelatin hydrolysate, sucrose, dextrose, polyvinylpyrrolidone (PVP), polyethyleneglycol (PEG), vinyl pyrrolidone copolymers, pregelatinized starch, sorbitol, glucose, Kollidon, and polyacrylates.
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