US 11,708,338 B2
Substituted phenyl sulfonyl phenyl triazole thiones and uses thereof
Wolfgang J. Wrasidlo, La Jolla, CA (US); Emily M. Stocking, Encinitas, CA (US); Srinivasa Reddy Natala, San Diego, CA (US); and Diana Luz Price, Escondido, CA (US)
Assigned to Neuropore Therapies, Inc., San Diego, CA (US)
Filed by Neuropore Therapies, Inc., San Diego, CA (US)
Filed on Apr. 6, 2021, as Appl. No. 17/223,989.
Application 17/223,989 is a division of application No. 16/663,054, filed on Oct. 24, 2019, granted, now 11,008,294.
Application 16/663,054 is a continuation of application No. 16/366,793, filed on Mar. 27, 2019, granted, now 10,501,423, issued on Dec. 10, 2019.
Application 16/366,793 is a continuation of application No. PCT/US2018/058050, filed on Oct. 29, 2018.
Claims priority of provisional application 62/584,630, filed on Nov. 10, 2017.
Claims priority of provisional application 62/579,070, filed on Oct. 30, 2017.
Prior Publication US 2021/0300881 A1, Sep. 30, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 249/12 (2006.01); A61P 25/28 (2006.01); A61K 9/10 (2006.01); A61P 3/00 (2006.01); C07D 243/10 (2006.01); A61K 31/18 (2006.01)
CPC C07D 249/12 (2013.01) [A61K 9/10 (2013.01); A61K 31/18 (2013.01); A61P 3/00 (2018.01); A61P 25/28 (2018.01); C07D 243/10 (2013.01)] 24 Claims
 
1. A pharmaceutical composition comprising (a) at least one compound of Formula (I),

OG Complex Work Unit Chemistry
wherein
R1, R2, and R3 are each independently hydrogen, hydroxy, halogen, optionally substituted C1-4 alkyl, optionally substituted C1-4 alkoxy, —CN, —C(O)Rx, —C(O)ORx, —S(O)2Rx, or —NRyRz;
Rx, Ry, and Rz are each independently H or optionally substituted C1-4alkyl, or Ry and Rz taken together with the nitrogen to which they are attached form an optionally substituted monocyclic heterocycloalkyl ring;
or a pharmaceutically acceptable salt thereof, and
(b) a pharmaceutically acceptable excipient,
wherein the pharmaceutically acceptable excipient is selected from the group consisting of a polymeric agent, carboxymethyl cellulose (CMC), hydroxypropyl cellulose (HPC), hydroxyethyl cellulose (HEC), hydroxypropylmethyl cellulose (HPMC), gelatin, gelatin hydrolysate, sucrose, dextrose, polyvinylpyrrolidone (PVP), polyethyleneglycol (PEG), vinyl pyrrolidone copolymers, pregelatinized starch, sorbitol, glucose, Kollidon, and polyacrylates.