US 11,708,322 B2
Process for preparation of 2,6-dichlorobenzonitrile
Kamal Kataria, Maharashtra (IN); Vic Prasad, Leawood, KS (US); Christopher Lynn Larson, Cary, NC (US); Cameron Seath Gibb, Apex, NC (US); Kirit Desai, Gujarat (IN); Ashwani Gupta, Gujarat (IN); and Girish Sisode, Gujarat (IN)
Assigned to ARYSTA LIFESCIENCE INC., Cary, NC (US)
Filed by Arysta LifeScience Inc., Cary, NC (US)
Filed on Nov. 15, 2019, as Appl. No. 16/685,703.
Claims priority of provisional application 62/768,407, filed on Nov. 16, 2018.
Prior Publication US 2020/0157043 A1, May 21, 2020
Int. Cl. C07C 253/30 (2006.01)
CPC C07C 253/30 (2013.01) 7 Claims
 
1. A process for producing 2,6-dichlorobenzonitrile comprising
a) cyanating 1,2-dichloro-3-nitro benzene in the presence of a catalytic amount of an aprotic amide to obtain 2-chloro-6-nitrobenzonitrile, wherein step a) is carried out in presence of sodium cyanide and copper cyanide, or sodium cyanide and copper chloride, or a mixture of sodium cyanide, copper chloride and copper cyanide, and
b) de-nitrochlorinating 2-chloro-6-nitrobenzonitrile with chlorine gas to obtain 2,6-dichlorobenzonitrile, wherein step (b) is performed for 5 to 15 hours without solvent and a molar ratio of 2-chloro-6-nitrobenzonitrile to chlorine gas is from 1:1 to 1:5.