CPC A61K 39/40 (2013.01) [A61K 39/04 (2013.01); A61P 31/06 (2018.01); C07K 16/1289 (2013.01); G01N 33/5695 (2013.01); G01N 33/56933 (2013.01); C07K 2317/21 (2013.01); C07K 2317/622 (2013.01); C07K 2317/92 (2013.01); G01N 2333/35 (2013.01); G01N 2400/02 (2013.01); G01N 2800/44 (2013.01)] | 9 Claims |
1. A monoclonal anti-lipoarabinomannan (anti-LAM) antibody, Or an antigen-binding portion thereof, that specifically binds to a LAM epitope comprising an Ara4 structure, an Ara6 structure, or a combination thereof, wherein the anti-LAM antibody comprises a CDR1 light chain variable region having at least 80% identity with SEQ ID NO: 1 or antigenic fragments thereof, a CDR2 light chain variable region having at least 80% identity with SEQ ID NO: 2 or antigenic fragments thereof, a CDR3 light chain variable region having at least 80% identity with SEQ ID NO: 3 or SEQ ID NO: 26 or antigenic fragments thereof, a CDR1 heavy chain variable region having at least 80% identity with SEQ ID NO: 4 or antigenic fragments thereof, a CDR2 heavy chain variable region having at least 80% identity with SEQ ID NO: 5 or antigenic fragments thereof, and a CDR3 heavy chain variable region having at least 80% identity with SEQ ID NO: 6 or SEQ ID NO: 23 or antigenic fragments thereof, having a modified heavy chain constant region.
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