CPC A61K 38/4893 (2013.01) [C12Y 304/24069 (2013.01)] | 14 Claims |
1. A nucleic acid for use as a drug and/or in therapeutic methods comprising a botulinum neurotoxin (BoNT)-encoding nucleic acid sequence, wherein the BoNT-encoding nucleic acid sequence is modified such that the linker region in the encoded protein between the light and heavy chains comprises a recognition motif for a protease and wherein the BoNT-encoding nucleic acid sequence, excluding the recognition motif for the protease, comprises a sequence according to SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4 and SEQ ID NO: 5 or a sequence having 80% sequence identity thereto.
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