CPC A61K 38/10 (2013.01) [A61K 39/00 (2013.01); C07K 16/36 (2013.01); C07K 2317/76 (2013.01)] | 20 Claims |
1. A polypeptide of the formula R1-Xaa0-Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa6-Xaa7-Xaa8-Xaa9-Xaa10-Xaa11-Xaa12-R2 (SEQ ID NO: 212), wherein:
a. R1 is absent or an acetyl group;
b. Xaa0 is absent or selected from the group consisting of norvaline and Ala;
c. Xaa1 is Cys;
d. Xaa2 is phenylglycine;
e. Xaa3 is Thr;
f. Xaa4 is selected from 7-azatryptophan and Trp;
g. Xaa5 is Glu;
h. Xaa6 is selected from the group consisting of Tyr, Phe, 4-fluorophenylalanine, and O-methyl-tyrosine;
i. Xaa7 is selected from the group consisting of Pro, N-methyl-serine, and N-methyl-alanine;
j. Xaa8 is selected from the group consisting of His and Ala;
k. Xaa9 is Cys;
l. Xaa10 is absent or selected from the group consisting of norvaline, and Ala;
m. Xaa11 is absent or Pro;
n. Xaa12 is absent or is norvaline; and
o. R2 is absent or —NH2.
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