	US 11,707,495 B2
	Recombinant rhabdovirus encoding for CCL21
Philipp Mueller, Mittelbiberach (DE); Klaus Erb, Mittelbiberach (DE); Patrik Erlmann, Goetzens (AT); Tobias Friederike Nolden, Birgitz (AT); John Edward Park, Warthausen (DE); and Guido Wollmann, Innsbruck (AT)
Assigned to Boehringer Ingelheim International GmbH, Ingelheim am Rhein (DE); and ViraTherapeutics GmbH, Rum (AT)
Filed by Boehringer Ingelheim International GmbH, Ingelheim am Rhein (DE); and ViraTherapeutics GmbH, Rum (AT)
Filed on Jan. 24, 2020, as Appl. No. 16/751,364.
Claims priority of application No. 19153668 (EP), filed on Jan. 25, 2019.
Prior Publication US 2020/0237838 A1, Jul. 30, 2020
Int. Cl. A61K 35/766 (2015.01); C12N 7/00 (2006.01); A61K 35/00 (2006.01); A61K 31/4375 (2006.01); A61P 35/00 (2006.01); A61K 9/00 (2006.01); A61K 31/4704 (2006.01); A61K 31/4725 (2006.01); A61K 31/506 (2006.01); A61K 31/5377 (2006.01); A61K 39/395 (2006.01); C07K 14/52 (2006.01)

CPC A61K 35/766 (2013.01) [A61K 9/0019 (2013.01); A61K 31/4375 (2013.01); A61K 31/4704 (2013.01); A61K 31/4725 (2013.01); A61K 31/506 (2013.01); A61K 31/5377 (2013.01); A61K 39/3955 (2013.01); A61P 35/00 (2018.01); C07K 14/521 (2013.01); C12N 7/00 (2013.01); C12N 2760/20221 (2013.01)]

34 Claims

1. A recombinant vesicular stomatitis virus encoding in its genome at least one human CCL21 protein having a c-terminal truncation wherein said truncated CCL21 protein comprises the amino acids 1-79, 1-81, 1-88, or 1-91, as shown in SEQ ID NO:2 and having at least 80% identity to SEQ ID NO:3, and wherein the gene coding for the glycoprotein G of the recombinant vesicular stomatitis virus is replaced by the gene coding for the glycoprotein GP of Lymphocyte choriomeningitis virus (LCMV), and/or the glycoprotein G is replaced by the glycoprotein GP of LCMV.