CPC A61K 9/5153 (2013.01) [A61K 9/0014 (2013.01); A61K 9/06 (2013.01); A61K 9/7015 (2013.01); A61K 31/35 (2013.01); A61K 47/10 (2013.01); A61K 47/22 (2013.01); A61K 47/36 (2013.01); A61K 47/44 (2013.01); A61P 25/02 (2018.01)] | 14 Claims |
1. A nanoparticle comprising resiniferatoxin (RTX) encapsulated in a poly(lactic-co-glycolic acid) (PLGA) polymer for topical application, the nanoparticle having a size in the range from 5 nm to 100 nm, wherein the nanoparticle penetrates the transdermal skin barrier and wherein resiniferatoxin is loaded in the nanoparticle in a concentration ranging from 100 femtomoles (fM) to one micromole (μM).
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