CPC A61K 9/08 (2013.01) [A61K 31/4174 (2013.01); A61K 31/4725 (2013.01); A61K 31/497 (2013.01); A61K 31/7036 (2013.01); A61K 38/14 (2013.01); A61M 3/0204 (2014.02); A61M 3/0229 (2013.01)] | 15 Claims |
1. A method for the treatment of diabetic foot ulcers using water-soluble anti-infective medication, comprising administering to a subject an effective amount of an irrigation therapy solution consisting of about 1 gram to about 10 grams of a pharmaceutical composition dissolved in a volume of about 1.5 to about 5 liters of water,
wherein the pharmaceutical composition comprises:
a first antimicrobial agent, a second antimicrobial agent, a third antimicrobial agent, and a powder excipient base;
wherein the first antimicrobial agent is an aminoglycoside antibiotic or a fluoroquinolone, and is present in an amount of from about 15 wt % to about 35 wt %;
wherein the second antimicrobial agent is glycopeptide antibiotic, and is present in an amount of from about 15 wt % to about 40 wt %;
wherein the third antimicrobial agent is an azole antifungal or an imidazole antifungal, and is present in an amount of from about 1 wt % to about 15 wt %;
wherein the powder excipient base is present in an amount of from about 10 wt % to about 50 wt %;
wherein the wt % is based on the total weight of the first antimicrobial agent, the second antimicrobial agent, the third antimicrobial agent, and the powder excipient base such that the total wt % for foregoing components is 100 wt %; and
wherein the first antimicrobial agent, the second antimicrobial agent, the third antimicrobial agent, and the powder excipient base are a homogeneously dispersed powder mixture prior to being dissolved;
wherein the subject is diagnosed with diabetes;
wherein the irrigation therapy solution is contained in a suitable irrigation therapy delivery device;
wherein administering comprises the subject placing at least one foot in the irrigation therapy delivery device for a suitable period of time.
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