CPC A61K 9/0075 (2013.01) [A24F 42/20 (2020.01); A61K 31/465 (2013.01)] | 14 Claims |
1. A method of controlling the harshness of nicotine inhaled by a subject, the method comprising the steps of:
identifying a concentration of nicotine for a dry powder formulation comprising nicotine particles for a subject to inhale based on a desired level of harshness per inhalation, the nicotine particles comprising nicotine salt and sugar;
providing the subject with a first dose comprising a first amount of the formulation having the identified concentration of nicotine;
providing the subject with a second dose comprising a second amount of the formulation, the second dose comprising a lower amount of nicotine than the first dose; and
providing the subject with a third dose comprising a third amount of the formulation, the third dose comprising a lower amount of nicotine than the second dose,
wherein at least one of the second and third doses has a concentration that is higher than the identified concentration of the first dose to increase the harshness of the nicotine inhaled by the subject.
|