US 11,707,432 B2
System and method for controlling the harshness of nicotine-based dry powder formulations
Alex Stenzler, Long Beach, CA (US); Noe Zamel, Toronto (CA); Arthur Slutsky, Toronto (CA); Steven Ellis, Oro-Medonte (CA); and Steve Han, Huntington Beach, CA (US)
Assigned to Philip Morris Products S.A., Neuchâtel (CH)
Filed by PHILIP MORRIS PRODUCTS S.A., Neuchâtel (CH)
Filed on Jul. 25, 2019, as Appl. No. 16/521,913.
Application 16/521,913 is a division of application No. 14/856,116, filed on Sep. 16, 2015, abandoned.
Prior Publication US 2019/0343178 A1, Nov. 14, 2019
Int. Cl. A61K 9/00 (2006.01); A61K 31/465 (2006.01); A24F 42/20 (2020.01)
CPC A61K 9/0075 (2013.01) [A24F 42/20 (2020.01); A61K 31/465 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A method of controlling the harshness of nicotine inhaled by a subject, the method comprising the steps of:
identifying a concentration of nicotine for a dry powder formulation comprising nicotine particles for a subject to inhale based on a desired level of harshness per inhalation, the nicotine particles comprising nicotine salt and sugar;
providing the subject with a first dose comprising a first amount of the formulation having the identified concentration of nicotine;
providing the subject with a second dose comprising a second amount of the formulation, the second dose comprising a lower amount of nicotine than the first dose; and
providing the subject with a third dose comprising a third amount of the formulation, the third dose comprising a lower amount of nicotine than the second dose,
wherein at least one of the second and third doses has a concentration that is higher than the identified concentration of the first dose to increase the harshness of the nicotine inhaled by the subject.