US 11,707,419 B2
Composite particles including anionic polymer and cationic polymer or peptide, and method for producing composite particles
Ryota Hayashi, Kanagawa (JP)
Assigned to POLA CHEMICAL INDUSTRIES, INC., Shizuoka (JP)
Appl. No. 16/340,350
Filed by POLA CHEMICAL INDUSTRIES, INC., Shizuoka (JP)
PCT Filed Oct. 4, 2017, PCT No. PCT/JP2017/036146
§ 371(c)(1), (2) Date Apr. 8, 2019,
PCT Pub. No. WO2018/074237, PCT Pub. Date Apr. 26, 2018.
Claims priority of application No. JP2016-203809 (JP), filed on Oct. 17, 2016; and application No. JP2016-204693 (JP), filed on Oct. 18, 2016.
Prior Publication US 2019/0231655 A1, Aug. 1, 2019
Int. Cl. A61K 8/02 (2006.01); A61K 8/73 (2006.01); A61Q 19/00 (2006.01); A61K 8/64 (2006.01); A61K 8/65 (2006.01); A61K 8/88 (2006.01); A61K 8/81 (2006.01); A61K 9/10 (2006.01); A61P 43/00 (2006.01); A61K 31/728 (2006.01); A61P 17/00 (2006.01); A61K 38/02 (2006.01)
CPC A61K 8/0241 (2013.01) [A61K 8/64 (2013.01); A61K 8/65 (2013.01); A61K 8/73 (2013.01); A61K 8/735 (2013.01); A61K 8/81 (2013.01); A61K 8/88 (2013.01); A61K 9/10 (2013.01); A61K 31/728 (2013.01); A61K 38/02 (2013.01); A61P 17/00 (2018.01); A61P 43/00 (2018.01); A61Q 19/00 (2013.01)] 3 Claims
OG exemplary drawing
 
1. A composite particle, consisting of: anionic polymers; and a cationic polymer (except for chitosan) having a degree of cationization of 0.2 or more,
the anionic polymers consist of hyaluronan, salt of hyaluronan, or combination thereof,
the cationic polymer is one of diallyldimethylamine hydrochloride polymer, allylamine hydrochloride polymer, diallylamine hydrochloride polymer, methyl diallylamine hydrochloride polymer, acrylamide-diallyldimethylamine hydrochloride copolymer, arginine/lysine oligopeptide, polylysine, and protamine,
an average particle diameter of the composite particle is 100 nm to 500 nm, and
a mass ratio of the anionic polymers to the cationic polymer in the composite particle is 10:1 to 1:10.