US 11,703,800 B2
Methods for temporal and spatial multiplexing of spatial light modulators and systems for same
James Marshel, Stanford, CA (US); and Karl A. Deisseroth, Stanford, CA (US)
Assigned to The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US)
Appl. No. 16/957,926
Filed by The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US)
PCT Filed Mar. 21, 2019, PCT No. PCT/US2019/023403
§ 371(c)(1), (2) Date Jun. 25, 2020,
PCT Pub. No. WO2019/183376, PCT Pub. Date Sep. 26, 2019.
Claims priority of provisional application 62/792,752, filed on Jan. 15, 2019.
Claims priority of provisional application 62/646,244, filed on Mar. 21, 2018.
Prior Publication US 2021/0063964 A1, Mar. 4, 2021
Int. Cl. G03H 1/22 (2006.01); A61N 5/06 (2006.01); G03H 1/00 (2006.01); A61N 5/073 (2006.01)
CPC G03H 1/2294 (2013.01) [A61N 5/0622 (2013.01); G03H 1/0005 (2013.01); G03H 1/2286 (2013.01); A61N 2005/0659 (2013.01); A61N 2005/0662 (2013.01); A61N 2005/073 (2013.01)] 30 Claims
OG exemplary drawing
 
1. A method for selectively stimulating a plurality of light-responsive neurons in a sample, the method comprising:
irradiating a sample comprising a plurality of light-responsive neurons with a plurality of holographic images that are each configured to stimulate one or more light-responsive neurons in the sample, wherein the holographic images are created by light projection system that includes:
a plurality of light sources;
a plurality of optical adjustment components;
a plurality of spatial light modulators;
a controller;
a processor; and
a computer-readable medium comprising instructions that, when executed by the processor, cause the controller to:
operate the light sources, optical adjustment components and spatial light modulators to generate and display a plurality of holographic images, wherein light beams from the light sources are combined by orthogonal polarization;
direct each of the holographic images to a projection location; and
project the holographic images onto the sample at a rate greater than or equal to 1 kHz.