US 11,703,441 B2
Method for predicting onset of cerebral infarction, method for determining therapeutic effect of erythropoietic factor preparation, and method for determining stage of chronic kidney
Hiromi Kataoka, Kurashiki (JP); Yutaka Yatomi, Tokyo (JP); Akiko Masuda, Tokyo (JP); Hironori Shimosaka, Toyko (JP); and Hajimu Kawakami, Kobe (JP)
Assigned to KAWASAKI GAKUEN Educational Foundation, Kurashiki (JP); THE UNIVERSITY OF TOKYO, Tokyo (JP); and SYSMEX CORPORATION, Kobe (JP)
Filed by KAWASAKI GAKUEN Educational Foundation, Kurashiki (JP); THE UNIVERSITY OF TOKYO, Tokyo (JP); and SYSMEX CORPORATION, Kobe (JP)
Filed on Sep. 28, 2018, as Appl. No. 16/145,824.
Claims priority of application No. 2017-190676 (JP), filed on Sep. 29, 2017.
Prior Publication US 2019/0101483 A1, Apr. 4, 2019
Int. Cl. G01N 15/10 (2006.01); G01N 15/14 (2006.01); G01N 33/49 (2006.01); G16H 50/20 (2018.01); G16H 50/30 (2018.01); G01N 15/00 (2006.01)
CPC G01N 15/1031 (2013.01) [G01N 15/14 (2013.01); G16H 50/20 (2018.01); G16H 50/30 (2018.01); G01N 15/1459 (2013.01); G01N 33/49 (2013.01); G01N 2015/0073 (2013.01); G01N 2015/1006 (2013.01); G01N 2015/1062 (2013.01); G01N 2015/1486 (2013.01)] 7 Claims
OG exemplary drawing
 
1. A method for assisting determination of a therapeutic effect by an erythropoietic factor preparation, comprising the steps of:
in a blood sample collected from a subject at a first time point, measuring a red blood cell count without treating red blood cells with a surfactant before measurement, measuring the red blood cell count after treating red blood cells with a surfactant, calculating a first exponent value from a first measured value indicating red blood cell count measured by electrical resistance measurement method and a second measured value indicating red blood cell count measured by optical measurement method;
administering the erythropoietic factor preparation to the subject;
for a blood sample collected from a subject at a second time point after administration of the erythropoietic factor preparation and after the first time point, calculating a second exponent value from a third measured value indicating red blood cell count measured by electrical resistance measurement method and a fourth measured value indicating red blood cell count measured by optical measurement method,
comparing the first exponent value with the second exponent value; and
determining, by a determination apparatus, that the erythropoietic factor preparation works well in the subject when the second exponent value is determined to be improved over the first exponent value.