CPC C08F 261/04 (2013.01) [A61K 9/0024 (2013.01); A61K 9/1635 (2013.01); A61K 49/0442 (2013.01); A61L 24/001 (2013.01); A61L 24/0015 (2013.01); A61L 24/046 (2013.01); C08G 67/00 (2013.01); A61L 2400/06 (2013.01); A61L 2430/36 (2013.01)] | 17 Claims |
1. A radiopaque microsphere comprising a hydrophilic polymer comprising pendent groups of the formula I:
wherein:
W is independently selected from —OH, —COOH, —SO3H, —OPO3H, —O—(C1-4 alkyl), —O—(C1-4 alkyl)OH, —O—(C1-4 alkyl)R2, —O—(C2H5O)qR1—(C═O)—O—C1-4 alkyl and —O—(C═O)C1-4 alkyl; or a group —BZ; wherein —OH, COOH, O—PO3H and SO3H maybe in the form of a pharmaceutically acceptable salt;
wherein:
B is a bond, or a straight branched alkanediyl, oxyalkylene, alkylene oxaalkylene, or alkylene group, optionally containing one or more fluorine substituents;
Z is an ammonium, phosphonium, or sulphonium phosphate or phosphonate ester zwitterionic group;
X is either a bond or a linking group having 1 to 8 carbons and optionally 1 to 4 heteroatoms selected from O, N and S;
G is a coupling group through which the group of the formula I is coupled to the polymer and is selected from 1,3 dioxolane and 1,3 dioxane;
R1 is H or C1-4 alkyl;
R2 is —COOH, —SO3H, or —OPO3H2
q is an integer from 1 to 4;
n is an integer from 1 to 4;
p is an integer from 1 to 3; and
n+p is from 2 to 5; and
wherein —COOH, —OPO3H2 and —SO3H as well as phenolic —OH may be in the form of a pharmaceutically acceptable salt.
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