CPC C07K 16/2878 (2013.01) [A61P 35/00 (2018.01); A61K 2039/505 (2013.01); C07K 2317/565 (2013.01); C07K 2317/75 (2013.01)] | 13 Claims |
1. An agonistic monoclonal antibody, or an antigen-binding fragment thereof, that specifically binds to the human CD40 receptor and is capable of inducing CD40 signaling independent of Fcγ mediated CD40 receptor crosslinking;
wherein the antibody comprises a variable heavy (VH) region that is at least 85% identical to SEQ ID NO: 5 and comprises CDR regions CDR1H, CDR2H, and CDR3H as set forth in SEQ ID NO: 33, SEQ ID NO: 47, and SEQ ID NO: 61, respectively; and
wherein the antibody comprises a variable light (VL) region that is at least 85% identical to SEQ ID NO: 19 and comprises CDR regions CDR1L, CDR2L, and CDR3L as set forth in SEQ ID NO: 75, SEQ ID NO: 89, and SEQ ID NO: 103, respectively.
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