US 11,702,445 B2
Automated synthesis reactor system with a recirculation loop
Olivier Ludemann-Hombourger, La Wantzenau (FR); Isabelle Martinuzzi, Martigues (FR); Christelle Bobier, Vellinge (SE); and Eric Francomme, Vandoeuvre (FR)
Assigned to POLYPEPTIDE LABORATOIRES FRANCE, Strasbourg (FR)
Appl. No. 17/46,391
Filed by POLYPEPTIDE LABORATOIRES FRANCE, Strasbourg (FR)
PCT Filed May 4, 2018, PCT No. PCT/FR2018/051142
§ 371(c)(1), (2) Date Oct. 9, 2020,
PCT Pub. No. WO2019/211531, PCT Pub. Date Nov. 7, 2019.
Prior Publication US 2021/0094982 A1, Apr. 1, 2021
Int. Cl. C07K 1/04 (2006.01); B01J 19/24 (2006.01); C07K 1/06 (2006.01); G01N 21/359 (2014.01); G01N 21/65 (2006.01); B01J 19/00 (2006.01); G01N 21/84 (2006.01)
CPC C07K 1/045 (2013.01) [B01J 19/00 (2013.01); B01J 19/24 (2013.01); B01J 19/2465 (2013.01); C07K 1/061 (2013.01); G01N 21/359 (2013.01); G01N 21/65 (2013.01); B01J 2219/24 (2013.01); G01N 2021/8416 (2013.01)] 2 Claims
OG exemplary drawing
 
1. A reactor system for performing a solid-phase peptide synthesis, the reactor system comprising:
an inlet pipe dedicated to the introduction of resin;
an inlet pipe dedicated to the introduction of a synthesis and washing solvent;
an inlet pipe dedicated to the introduction of a deprotecting agent of an amino acid supplied;
an inlet pipe dedicated to the introduction of reagents;
an assembly reactor;
a recirculation loop of a liquid in the assembly reactor comprising at least one measuring cell for indirect quantification of the progress of the reaction on the solid phase; and
a level sensor to determine a height of the liquid in the assembly reactor with respect to a height of a bed of the resin.