CPC C07D 487/04 (2013.01) [A61K 9/2095 (2013.01); A61K 9/4833 (2013.01); A61P 25/00 (2018.01); C07D 471/04 (2013.01)] | 18 Claims |
1. A compound or salt selected from:
N-((6-fluoro[1,2,3]triazolo[1,5-a]pyridin-3-yl)methyl)-4-(trifluoromethoxy)benzamide;
N-((4(4-methyl[1,2,3]triazolo[1,5-a]pyridin-3-yl)methyl)-4-(trifluoromethoxy)benzamide;
3-chloro-4-(difluoromethoxy)-N-((4-methyl[1,2,3]triazolo[1,5-a]pyridin-3-yl)methyl)benzamide;
5-fluoro-6-methoxy-N-(pyrazolo[1,5-b]pyridazin-3-ylmethyl)nicotinamide;
3-fluoro-N-(pyrazolo[1,5-b]pyridazin-3-ylmethyl)-4-(trifluoromethoxy)benzamide;
6-(difluoromethoxy)-5-fluoro-N-(pyrazolo[1,5-b]pyridazin-3-ylmethyl)nicotinamide;
3-chloro-4-(difluoromethoxy)-N-(pyrazolo[1,5-b]pyridazin-3-ylmethyl)benzamide;
5-chloro-6-(difluoromethoxy)-N-(pyrazolo[1,5-b]pyridazin-3-ylmethyl)nicotinamide;
5-chloro-6-methoxy-N-(pyrazolo[1,5-b]pyridazin-3-ylmethyl)nicotinamide;
3-fluoro-N-((2-methylpyrazolo[1,5-b]pyridazin-3-yl)methyl)-4-(trifluoromethoxy)benzamide;
3-fluoro-N-((6-methylpyrazolo[1,5-b]pyridazin-3-yl)methyl)-4-(trifluoromethoxy)benzamide;
3,5-difluoro-4-methoxy-N-(pyrazolo[1,5-b]pyridazin-3-ylmethyl)benzamide;
3-fluoro-N-([1,2,3]triazolo[1,5-a]pyridin-3-ylmethyl)-4-(trifluoromethoxy)benzamide;
6-(difluoromethoxy)-5-fluoro-N-([1,2,3]triazolo[1,5-a]pyridin-3-ylmethyl)nicotinamide;
4-(difluoromethoxy)-3-fluoro-N-(pyrazolo[1,5-b]pyridazin-3-ylmethyl)benzamide;
3-fluoro-N-(pyrazolo[1,5-a]pyrazin-3-ylmethyl)-4-(trifluoromethoxy)benzamide;
6-(difluoromethoxy)-5-fluoro-N-((2-methylpyrazolo[1,5-b]pyridazin-3-yl)methyl)nicotinamide;
3-fluoro-N-([1,2,3]triazolo[1,5-b]pyridazin-3-ylmethyl)-4-(trifluoromethoxy)benzamide;
N-([1,2,3]triazolo[1,5-b]pyridazin-3-ylmethyl)-4-(trifluoromethoxy)benzamide;
3-fluoro-N-((4-methylpyrazolo[1,5-b]pyridazin-3-yl)methyl)-4-(trifluoromethoxy)benzamide;
3-fluoro-N-((5-methylpyrazolo[1,5-b]pyridazin-3-yl)methyl)-4-(trifluoromethoxy)benzamide;
5-chloro-6-(difluoromethoxy)-N-([1,2,3]triazolo[1,5-b]pyridazin-3-ylmethyl)nicotinamide;
6-(difluoromethoxy)-5-fluoro-N-([1,2,3]triazolo[1,5-b]pyridazin-3-ylmethyl)nicotinamide;
6-(difluoromethoxy)-N-((2-ethoxypyrazolo[1,5-b]pyridazin-3-yl)methyl)-5-fluoronicotinamide;
4-(difluoromethoxy)-N-((2-ethoxypyrazolo[1,5-b]pyridazin-3-yl)methyl)-3-fluorobenzamide;
6-(difluoromethoxy)-N-((2-ethylpyrazolo[1,5-b]pyridazin-3-yl)methyl)-5-fluoronicotinamide;
4-(difluoromethoxy)-N-((2-ethylpyrazolo[1,5-b]pyridazin-3-yl)methyl)-3-fluorobenzamide;
N-((2-cyclopropylpyrazolo[1,5-b]pyridazin-3-yl)methyl)-6-(difluoromethoxy)-5-fluoronicotinamide;
N-((2-cyclopropylpyrazolo[1,5-b]pyridazin-3-yl)methyl)-4-(difluoromethoxy)-3-fluorobenzamide;
3-chloro-4-(difluoromethoxy)-N-([1,2,3]triazolo[1,5-b]pyridazin-3-ylmethyl)benzamide;
6-(difluoromethoxy)-5-fluoro-N-((2-(methoxymethyl)pyrazolo[1,5-b]pyridazin-3-yl)methyl)nicotinamide;
3-fluoro-N-((2-(methoxymethyl)pyrazolo[1,5-b]pyridazin-3-yl)methyl)-4-(trifluoromethoxy)benzamide;
4-(difluoromethoxy)-3-fluoro-N-([1,2,3]triazolo[1,5-b]pyridazin-3-ylmethyl)benzamide;
3-chloro-4-(difluoromethoxy)-N-([1,2,3]triazolo[1,5-a]pyridin-3-ylmethyl)benzamide;
4-(difluoromethoxy)-3-fluoro-N-([1,2,3]triazolo[1,5-a]pyridin-3-ylmethyl)benzamide;
4-(difluoromethoxy)-3-fluoro-N-((4-methylpyrazolo[1,5-b]pyridazin-3-yl)methyl)benzamide;
6-(difluoromethoxy)-5-fluoro-N-((4-methylpyrazolo[1,5-b]pyridazin-3-yl)methyl)nicotinamide;
4-(difluoromethoxy)-3-fluoro-N-((5-methylpyrazolo[1,5-b]pyridazin-3-yl)methyl)benzamide;
6-(difluoromethoxy)-5-fluoro-N-((5-methylpyrazolo[1,5-b]pyridazin-3-yl)methyl)nicotinamide;
3-chloro-N-([1,2,3]triazolo[1,5-b]pyridazin-3-ylmethyl)-4-(trifluoromethoxy)benzamide;
3,5-difluoro-4-methoxy-N-([1,2,3]triazolo[1,5-a]pyridin-3-ylmethyl)benzamide;
3-fluoro-N-([1,2,3]triazolo[1,5-a]pyrazin-3-ylmethyl)-4-(trifluoromethoxy)benzamide;
6-(difluoromethoxy)-N-((2-(difluoromethyl)pyrazolo[1,5-b]pyridazin-3-yl)methyl)-5-fluoronicotinamide;
4-(difluoromethoxy)-3-fluoro-N-(pyrazolo[1,5-a]pyrazin-3-ylmethyl)benzamide;
6-(difluoromethoxy)-5-fluoro-N-(pyrazolo[1,5-a]pyrazin-3-ylmethyl)nicotinamide;
5-chloro-6-(difluoromethoxy)-N-((2-methylpyrazolo[1,5-b]pyridazin-3-yl)methyl)nicotinamide;
3-fluoro-N-(pyrazolo[1,5-b][1,2,4]triazin-8-ylmethyl)-4-(trifluoromethoxy)benzamide;
3-fluoro-N-((2-methylpyrazolo[1,5-c]pyrimidin-3-yl)methyl)-4-(trifluoromethoxy)benzamide;
3-fluoro-N-((5-methyl[1,2,3]triazolo[1,5-b]pyridazin-3-yl)methyl)-4-(trifluoromethoxy)benzamide;
6-(difluoromethoxy)-5-fluoro-N((5-methyl[1,2,3]triazolo[1,5-b]pyridazin-3-yl)methyl)nicotinamide;
5-chloro-6-(difluoromethoxy)-N((5-methyl[1,2,3]triazolo[1,5-b]pyridazin-3-yl)methyl)nicotinamide;
3-fluoro-N-((4-methyl[1,2,3]triazolo[1,5-b]pyridazin-3-yl)methyl)-4-(trifluoromethoxy)benzamide;
6-(difluoromethoxy)-5-fluoro-N((4-methyl[1,2,3]triazolo[1,5-b]pyridazin-3-yl)methyl)nicotinamide;
5-chloro-6-(difluoromethoxy)-N((4-methyl[1,2,3]triazolo[1,5-b]pyridazin-3-yl)methyl)nicotinamide;
6-(difluoromethoxy)-5-fluoro-N-((2-methylpyrazolo[1,5-c]pyrimidin-3-yl)methyl)nicotinamide;
5-chloro-6-(difluoromethoxy)-N-((2-methylpyrazolo[1,5-c]pyrimidin-3-yl)methyl)nicotinamide;
3-fluoro-N-((1-methyl-1H-imidazo[1,2-b]pyrazol-7-yl)methyl)-4-(trifluoromethoxy)benzamide;
6-(difluoromethoxy)-5-fluoro-N-((1-methyl-1H-imidazo[1,2-b]pyrazol-7-yl)methyl)nicotinamide;
5-chloro-6-(difluoromethoxy)-N-((1-methyl-1H-imidazo[1,2-b]pyrazol-7-yl)methyl)nicotinamide;
4-(cyclopropyloxy)-N-((1-methyl-1H-imidazo[1,2-b]pyrazol-7-yl)methyl)benzamide;
5-fluoro-6-methoxy-N-((1-methyl-1H-imidazo[1,2-b]pyrazol-7-yl)methyl)nicotinamide;
3,5-difluoro-4-methoxy-N-((1-methyl-1H-imidazo[1,2-b]pyrazol-7-yl)methyl)benzamide;
4-chloro-3-fluoro-N-((1-methyl-1H-imidazo[1,2-b]pyrazol-7-yl)methyl)benzamide;
N-((1-methyl-1H-imidazo[1,2-b]pyrazol-7-yl)methyl)-6-(trifluoromethoxy)nicotinamide;
N-((1-methyl-1H-imidazo[1,2-b]pyrazol-7-yl)methyl)-5-(trifluoromethyl)thiophene-2-carboxamide;
N-((1-methyl-1H-imidazo[1,2-1D]pyrazol-7-yl)methyl)-4-(trifluoromethoxy)benzamide;
3-fluoro-N-((1-methyl-1H-imidazo[1,2-1D]pyrazol-7-yl)methyl)-4-(trifluoromethyl)benzamide;
3-fluoro-N-([1,2,3]triazolo[1,5-a]pyridin-3-ylmethyl)-4-(trifluoromethyl)benzamide;
N-([1,2,3]triazolo[1,5-a]pyridin-3-ylmethyl)-4-(trifluoromethoxy)benzamide;
6-(difluoromethoxy)-N-[(1,2-dimethyl-1H-pyrazolo[1,5-b][1,2,4]triazol-7-yl)methyl]-5-fluoropyridine-3-carboxamide;
N-[(1,2-dimethyl-1H-pyrazolo[1,5-b][1,2,4]triazol-7-yl)methyl]-3-fluoro-4-(trifluoromethoxy)benzamide;
5-chloro-6-(difluoromethoxy)-N-[(1,2-dimethyl-1H-pyrazolo[1,5-b][1,2,4]triazol-7-yl)methyl]pyridine-3-carboxamide;
6-(difluoromethoxy)-N-[(1,6-dimethyl-1H-imidazo[1,2-1D]pyrazol-7-yl)methyl]-5-fluoropyridine-3-carboxamide;
6-(difluoromethoxy)-N-{[1-(difluoromethyl)-2-methyl-1H-pyrazolo[1,5-b][1,2,4]triazol-7-yl]methyl}-5-fluoropyridine-3-carboxamide;
5-chloro-6-(difluoromethoxy)-N-{[1-(difluoromethyl)-2-methyl-1H-pyrazolo[1,5-b][1,2,4]triazol-7-yl]methyl}pyridine-3-carboxamide;
6-(difluoromethoxy)-N-{[1-(difluoromethyl)-1H-imidazo[1,2-1D]pyrazol-7-yl]methyl}-5-fluoropyridine-3-carboxamide;
5-chloro-N-{[1-(2,2-difluoroethyl)-2-methyl-1H-pyrazolo[1,5-b][1,2,4]triazol-7-yl]methyl}-6-(difluoromethoxy)pyridine-3-carboxamide;
N-{[1-(2,2-difluoroethyl)-2-methyl-1H-pyrazolo[1,5-b][1,2,4]triazol-7-yl]methyl}-3-fluoro-4-(trifluoromethoxy)benzamide;
N-{[1-(2,2-difluoroethyl)-1H-imidazo[1,2-1D]pyrazol-7-yl]methyl}-6-(difluoromethoxy)-5-fluoropyridine-3-carboxamide;
5-chloro-N-{[1-(2,2-difluoroethyl)-1H-imidazo[1,2-1D]pyrazol-7-yl]methyl}-6-(difluoromethoxy)pyridine-3-carboxamide;
N-{[1-(2,2-difluoroethyl)-1H-imidazo[1,2-1D]pyrazol-7-yl]methyl}-3-fluoro-4-(trifluoromethoxy)benzamide;
6-(difluoromethoxy)-5-fluoro-N-{[1-(2,2,2-trifluoroethyl)-1H-imidazo[1,2-b]pyrazol-7-yl]methyl}pyridine-3-carboxamide;
6-(difluoromethoxy)-N-[(1-ethyl-1H-imidazo[1,2-b]pyrazol-7-yl)methyl]-5-fluoropyridine-3-carboxamide;
5-chloro-6-(difluoromethoxy)-N-[(1-ethyl-1H-imidazo[1,2-b]pyrazol-7-yl)methyl]pyridine-3-carboxamide;
6-(difluoromethoxy)-N-[(1,2-dimethyl-1H-imidazo[1,2-b]pyrazol-7-yl)methyl]-5-fluoropyridine-3-carboxamide;
and salts of any of the foregoing.
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