CPC C07D 487/04 (2013.01) [C07D 237/34 (2013.01); C07D 403/04 (2013.01); C07D 409/12 (2013.01); C07D 409/14 (2013.01); C07D 413/04 (2013.01); C07D 471/04 (2013.01); C07D 471/08 (2013.01); C07D 471/10 (2013.01); C07D 487/08 (2013.01); C07D 487/10 (2013.01); C07D 498/10 (2013.01)] | 72 Claims |
1. A compound of Formula (I):
or a pharmaceutically acceptable salt thereof,
wherein:
R1 is hydrogen, hydroxyl, C1-C6 alkyl, alkoxy, —N(R6)2, —NR6C(O)R6, —C(O)N(R6)2, —SO2alkyl, —SO2NR6alkyl, cycloalkyl, -Q-heterocyclyl, aryl, or heteroaryl, wherein the cycloalkyl, the heterocyclyl, the aryl, and the heteroaryl are each optionally substituted with one or more R2 or L-R2;
each Q is independently a bond, O, or NR6;
X is N;
each R2 is independently C1-C3 alkyl, oxo, hydroxy, halogen, cyano, hydroxyalkyl, haloalkyl, alkoxy, —C(O)N(R6)2, —N(R6)2, —SO2alkyl, —NR6C(O)C1-C3 alkyl, —C(O)cycloalkyl, —C(O)C1-C3 alkyl, —C(O)heterocyclyl, aryl, heteroaryl or heterocyclyl,
wherein the cycloalkyl, the heterocyclyl, the aryl, the heteroaryl or the heterocyclyl are each optionally substituted with one or more R11;
R3 is hydrogen, C1-C6 alkyl, alkoxy, —N(R10)2, -L-N(R10)2, cycloalkyl, haloalkyl or heterocyclyl, wherein the C1-C6 alkyl, the cycloalkyl and the heterocyclyl, are each optionally substituted with one or more R9;
Y is a bond or heteroarylene;
R4 is aryl or heteroaryl, each optionally substituted with one or more R5;
each R5 is independently hydroxy, halogen, cyano, hydroxyalkyl, alkoxy, C1-C3 alkyl, haloalkyl, haloalkyl-OH, —N(R6)2, -L-N(R6)2 or —SO2alkyl;
L is C1-C3 alkylene;
each R6 is independently hydrogen, C1-C3 alkyl, haloalkyl, or cycloalkyl;
R7 is hydrogen, cyano, CF3, F, or alkoxy;
R8 is C1-C2 alkyl or halo-C1-C2 alkyl;
each R9 is independently hydroxy, halogen, amino, cyano, alkoxy, or C1-C3 alkyl;
each R10 is independently hydrogen, C1-C3 alkyl or cycloalkyl;
each R11 is independently C1-C3 alkyl, halogen or haloalkyl; and
R12 is hydrogen, halogen or C1-C3 alkyl.
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