US 11,701,658 B2
Systems and methods for microfluidic particle selection, encapsulation, and injection using surface acoustic waves
Kiryakos Spiro Mutafopulos, Somerville, MA (US)
Assigned to President and Fellows of Harvard College, Cambridge, MA (US)
Filed by President and Fellows of Harvard College, Cambridge, MA (US)
Filed on Aug. 10, 2020, as Appl. No. 16/989,570.
Claims priority of provisional application 62/885,000, filed on Aug. 9, 2019.
Prior Publication US 2021/0039105 A1, Feb. 11, 2021
Int. Cl. B01L 3/00 (2006.01); G01N 15/14 (2006.01); G01N 15/10 (2006.01)
CPC B01L 3/502769 (2013.01) [B01L 3/502761 (2013.01); G01N 15/1404 (2013.01); G01N 15/1484 (2013.01); B01L 2200/027 (2013.01); B01L 2200/0652 (2013.01); B01L 2300/0627 (2013.01); B01L 2300/0861 (2013.01); B01L 2400/0436 (2013.01); G01N 2015/1006 (2013.01); G01N 2015/142 (2013.01); G01N 2015/149 (2013.01)] 22 Claims
OG exemplary drawing
 
1. A microfluidic system, comprising:
a substrate;
a dispersion phase fluidic channel formed in the substrate;
a continuous phase fluidic channel formed in the substrate and in fluid communication with the dispersion phase fluidic channel through an aperture in a channel wall therebetween;
an interdigital transducer (IDT) in contact with the substrate and configured to generate a surface acoustic wave to inject fluid from the dispersion phase fluidic channel into the continuous phase fluidic channel through the aperture,
wherein a channel height of the dispersion phase fluidic channel is less than a channel height of the continuous phase fluidic channel, and
wherein actuation of the IDT encapsulates and shifts a location of a particle from the dispersion phase fluidic channel to the continuous phase fluidic channel.