US 11,701,450 B2
Injectable silk fibroin foams and uses thereof
Gary G. Leisk, Somerville, MA (US); Tim Jia-Ching Lo, Taoyuan (TW); Lei Li, Beijing (CN); Evangelia Bellas, Philadelphia, PA (US); and David L. Kaplan, Concord, MA (US)
Assigned to TRUSTEES OF TUFTS COLLEGE, Medford, MA (US)
Filed by Trustees of Tufts College, Medford, MA (US)
Filed on Sep. 22, 2016, as Appl. No. 15/273,327.
Application 15/273,327 is a continuation of application No. 14/357,420, granted, now 9,492,504, previously published as PCT/US2012/064471, filed on Nov. 9, 2012.
Claims priority of provisional application 61/557,610, filed on Nov. 9, 2011.
Prior Publication US 2017/0007738 A1, Jan. 12, 2017
This patent is subject to a terminal disclaimer.
Int. Cl. A61L 27/56 (2006.01); A61L 27/50 (2006.01); A61L 27/22 (2006.01); A61L 27/36 (2006.01); A61L 27/38 (2006.01); A61L 27/48 (2006.01); A61L 27/54 (2006.01); A61K 38/17 (2006.01); A61L 27/58 (2006.01)
CPC A61L 27/227 (2013.01) [A61K 38/1767 (2013.01); A61L 27/3604 (2013.01); A61L 27/3834 (2013.01); A61L 27/48 (2013.01); A61L 27/50 (2013.01); A61L 27/54 (2013.01); A61L 27/56 (2013.01); A61L 27/58 (2013.01); A61L 2400/06 (2013.01); A61L 2400/08 (2013.01); A61L 2430/34 (2013.01)] 25 Claims
 
1. A method for augmenting a soft tissue in a subject, comprising injecting into the soft tissue to be augmented a composition from an injection applicator, the composition comprising
(i) a silk fibroin foam;
(ii) at least one additional material selected from the group consisting of collagen, gelatin, elastin, glycosaminoglycans, hyaluronic acid, and poly(lactic acid),
wherein the silk fibroin foam has a porosity of at least 50% with pores having a size of about 1 μm to about 1500 μm, the pores forming interconnected void spaces throughout a total volume and surface of the silk fibroin foam,
wherein the silk fibroin foam is in a compressed state prior to injection and expands from the compressed state upon injection into the soft tissue, and
wherein the silk fibroin foam does not comprise a hydrogel material; and
(iii) a carrier in fluid communication with the interconnected void spaces of the silk fibroin foam, and
wherein the silk fibroin foam and the injection applicator are dimensioned relative to one another to provide compression of the silk fibroin foam when located within the injection applicator prior to injection.