US 11,701,434 B2
Tertiary amino lipidated cationic peptides for nucleic acid delivery
Colin James McKinlay, Fremont, CA (US)
Assigned to NUTCRACKER THERAPEUTICS, INC., Emeryville, CA (US)
Filed by Nutcracker Therapeutics, Inc., Emeryville, CA (US)
Filed on Jun. 14, 2021, as Appl. No. 17/347,498.
Application 17/347,498 is a continuation of application No. 17/279,508, previously published as PCT/US2019/053655, filed on Sep. 27, 2019.
Claims priority of provisional application 62/885,036, filed on Aug. 9, 2019.
Claims priority of provisional application 62/738,717, filed on Sep. 28, 2018.
Prior Publication US 2021/0371458 A1, Dec. 2, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 48/00 (2006.01); A61K 9/51 (2006.01); A61K 47/00 (2006.01); C07K 7/06 (2006.01); C07K 7/08 (2006.01); A61K 47/54 (2017.01); A61K 31/7105 (2006.01); A61K 47/10 (2017.01); C07K 2/00 (2006.01)
CPC A61K 48/0041 (2013.01) [A61K 9/5123 (2013.01); A61K 9/5146 (2013.01); A61K 31/7105 (2013.01); A61K 47/10 (2013.01); A61K 47/543 (2017.08); C07K 2/00 (2013.01); C07K 7/06 (2013.01); C07K 7/08 (2013.01)] 28 Claims
 
1. A tertiary amino lipidated and/or PEGylated cationic peptide compound of formula (I) or a salt thereof:

OG Complex Work Unit Chemistry
wherein:
s is an integer from 1 to 5;
R1 is —H
each R3 is independently selected from C8-C24alkyl;
R5 is selected from hydroxyalkyl, hydroxyether, and hydroxylheteroalkyl;
R7 is —H, alkyl, acyl, —OH, —OR7a, —NH2, -NHR7a, or a lipid moiety, wherein
R7a is alkyl, acyl, or a lipid moiety; and
each Ra and Rb are independently —H, C1-C4-alkyl, or a side chain moiety found on a naturally- or non-naturally-occurring amino acid.