US 11,701,432 B2
Polyglutamated antifolates and uses thereof
Clet Niyikiza, Gulph Mills, PA (US); and Victor Mandla Moyo, Ringoes, NJ (US)
Assigned to LE.A.F. HOLDINGS GROUP LLC, Gulph Mills, PA (US)
Filed by L.E.A.F. HOLDINGS GROUP LLC, Gulph Mills, PA (US)
Filed on Jul. 28, 2022, as Appl. No. 17/875,724.
Application 17/875,724 is a division of application No. 16/324,871, granted, now 11,534,498, previously published as PCT/US2017/046667, filed on Aug. 12, 2017.
Application 16/324,871 is a continuation of application No. 15/675,701, filed on Aug. 11, 2017, abandoned.
Application 15/675,701 is a continuation of application No. 15/675,695, filed on Aug. 11, 2017, abandoned.
Claims priority of provisional application 62/374,458, filed on Aug. 12, 2016.
Prior Publication US 2022/0370634 A1, Nov. 24, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 47/69 (2017.01); A61K 47/64 (2017.01); A61K 47/54 (2017.01); A61K 47/68 (2017.01); A61P 19/02 (2006.01); A61P 35/00 (2006.01); A61K 9/127 (2006.01); A61K 31/517 (2006.01); A61K 31/519 (2006.01); A61K 45/06 (2006.01); A61K 47/10 (2017.01); C07K 16/28 (2006.01); B82Y 5/00 (2011.01)
CPC A61K 47/6913 (2017.08) [A61K 9/1271 (2013.01); A61K 31/517 (2013.01); A61K 31/519 (2013.01); A61K 45/06 (2013.01); A61K 47/10 (2013.01); A61K 47/545 (2017.08); A61K 47/64 (2017.08); A61K 47/645 (2017.08); A61K 47/6801 (2017.08); A61K 47/6849 (2017.08); A61K 47/6911 (2017.08); A61P 19/02 (2018.01); A61P 35/00 (2018.01); C07K 16/28 (2013.01); A61K 2300/00 (2013.01); B82Y 5/00 (2013.01); C07K 2317/73 (2013.01)] 32 Claims
OG exemplary drawing
 
1. A liposomal polyglutamated antifolate composition (LPA) comprising a liposome encapsulated polyglutamated antifolate comprising glutamates linked by their gamma carboxyl groups, optionally wherein the liposome is pegylated (PLPA).