CPC A61K 47/6855 (2017.08) [A61K 45/06 (2013.01); A61K 47/65 (2017.08); A61K 47/6803 (2017.08); C07D 487/04 (2013.01); C07D 519/00 (2013.01); Y02P 20/582 (2015.11)] | 3 Claims |
1. A mixture of conjugates having the following formula:
where R10 and R11 either
(a) form a double bond between the carbon and nitrogen atoms to which they are bound; or
(b) are H and ORA respectively, where RA is selected from H and C1-4 alkyl;
where the average drug loading per antibody in the mixture of antibody-drug conjugates is from 1 to 8, and
where CBA is an antibody or an active fragment thereof.
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