CPC A61K 38/2013 (2013.01) [A61K 31/352 (2013.01); A61K 31/428 (2013.01); A61K 31/4365 (2013.01); A61K 31/4468 (2013.01); A61K 31/451 (2013.01); A61K 31/496 (2013.01); A61K 31/498 (2013.01); A61K 31/519 (2013.01); A61K 31/538 (2013.01); A61K 31/7064 (2013.01); A61K 31/7076 (2013.01); A61P 3/10 (2018.01); A61P 37/06 (2018.01)] | 14 Claims |
11. A method for treating an inflammatory disease in a subject in need thereof, comprising administering to the subject:
(i) an effective dose of NEDD8 activating enzyme (NAE) inhibitor
(ii) a low dose of IL-2 of from 0.05×106 IU/m2 to 5×106 IU/m2;
thereby increasing or restoring function of regulatory T lymphocytes (Tregs) and treating the inflammatory disease.
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