CPC A61K 36/9066 (2013.01) [A61K 31/12 (2013.01); A61K 45/06 (2013.01); A61K 47/44 (2013.01); A61P 35/00 (2018.01)] | 17 Claims |
1. A method of increasing T-cell infiltration in a tumor of a subject, such method comprising a step of administering a pharmaceutical composition to the subject, wherein the composition comprises:
(a) one or more high polarity compounds isolated from Curcuma longa using a high polarity solvent system having a dielectric constant of greater than about 25 and a relative polarity value of greater than about 0.6 and selected from the group consisting of proteins, polysaccharides, and peptides;
(b) one or more medium polarity compounds isolated from Curcuma longa using a medium polarity solvent system having a dielectric constant of about 5 to about 25 and a relative polarity value of about 0.25 to about 0.6 and selected from the group consisting of polyphenols, curcumin, demethoxycurcumin, and bisdemethoxycurcumin; and
(c) one or more non-polar compounds isolated from Curcuma longa using a non-polar solvent system having a dielectric constant of less than about 5 and a relative polarity value of less than about 0.2 and selected from the group consisting of terpenoids, ar-turmerone, α-turmerone, and β-turmerone;
wherein the tumor is oral squamous cell carcinoma.
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