US 11,701,374 B1
8-hydroxy quinoline derivatives for enhancing telomerase reverse transcriptase (TERT) expression
William H. Andrews, Reno, NV (US); Lancer K. Brown, Sparks, NV (US); Laura A. Briggs, Reno, NV (US); Federico C. A. Gaeta, Mountain View, CA (US); Hamid Mohammadpour, Reno, NV (US); and Mieczyslaw A. Piatyszek, Gainesville, FL (US)
Assigned to Sierra Sciences, Inc., Reno, NV (US)
Filed by William H. Andrews, Reno, NV (US); Lancer K. Brown, Sparks, NV (US); Laura A. Briggs, Reno, NV (US); Federico C. A. Gaeta, Mountain View, CA (US); Hamid Mohammadpour, Reno, NV (US); and Mieczyslaw A. Piatyszek, Gainesville, FL (US)
Filed on May 18, 2011, as Appl. No. 13/110,583.
Claims priority of provisional application 61/345,980, filed on May 18, 2010.
Int. Cl. A61K 31/70 (2006.01); A61K 31/7052 (2006.01); A61K 31/47 (2006.01); A61K 31/4709 (2006.01)
CPC A61K 31/70 (2013.01) [A61K 31/47 (2013.01); A61K 31/4709 (2013.01); A61K 31/7052 (2013.01)] 4 Claims
 
1. A method for enhancing telomerase reverse transcriptase (TERT) expression in a cell, the method comprising:
contacting the cell with a TERT expression enhancing effective amount of a compound of the structure of formula (II):

OG Complex Work Unit Chemistry
wherein R1 is selected from hydroxyl, an alkoxy, an aryloxy, an acyloxy and OR101 where 8101 is a sugar; and
R2, R3, R4, R5, R6 and R7 are independently selected from hydrogen, an aliphatic, an aryl, an alkoxy, an aryloxy, an acyloxy, an amino, a carboxyamide, a carboxy, an acyl, an alkoxycarbonyl, an aminocarbonyl, a cyano, a halogen, a heterocycle, a hydroxyl, a nitro, a thio, an aminosulfonyl, an alkylsulfonyl, an arylsulphonyl and —SO3H wherein R1 and R2, R6 and R7 or R3 and R4 are cyclically linked.