US 11,701,373 B2
Substituted bicyclic compounds
Alaric J. Dyckman, Lawrenceville, NJ (US); T. G. Murali Dhar, Newtown, PA (US); Hai-Yun Xiao, Belle Mead, NJ (US); John L. Gilmore, Yardley, PA (US); Michael G. Yang, Narberth, PA (US); Zili Xiao, East Windsor, NJ (US); and David Marcoux, Pennington, NJ (US)
Assigned to Bristol-Myers Squibb Company, Princeton, NJ (US)
Filed by BRISTOL-MYERS SQUIBB COMPANY, Princeton, NJ (US)
Filed on May 4, 2021, as Appl. No. 17/307,138.
Application 15/337,843 is a division of application No. 14/831,439, filed on Aug. 20, 2015, granted, now 9,522,888.
Application 17/307,138 is a continuation of application No. 16/879,824, filed on May 21, 2020, granted, now 11,058,696.
Application 16/879,824 is a continuation of application No. 16/188,444, filed on Nov. 13, 2018, granted, now 10,709,719.
Application 16/188,444 is a continuation of application No. 15/648,250, filed on Jul. 12, 2017, granted, now 10,166,249.
Application 15/648,250 is a continuation of application No. 15/337,843, filed on Oct. 28, 2016, granted, now 9,770,459.
Claims priority of provisional application 62/039,622, filed on Aug. 20, 2014.
Prior Publication US 2022/0331346 A1, Oct. 20, 2022
Int. Cl. A61K 31/695 (2006.01); C07F 7/08 (2006.01); A61K 31/135 (2006.01); C07D 215/14 (2006.01); C07D 241/04 (2006.01); C07C 323/29 (2006.01); C07C 251/38 (2006.01); C07C 251/42 (2006.01); C07C 251/44 (2006.01); C07D 209/46 (2006.01); C07D 213/38 (2006.01); C07C 275/26 (2006.01); C07C 217/74 (2006.01); C07C 323/25 (2006.01); C07C 235/46 (2006.01); C07F 9/54 (2006.01); C07F 9/572 (2006.01); C07F 9/09 (2006.01); C07C 215/42 (2006.01); C07C 217/52 (2006.01); C07C 217/58 (2006.01); C07C 219/24 (2006.01); C07C 233/41 (2006.01); C07C 233/65 (2006.01); C07C 251/50 (2006.01); C07C 251/52 (2006.01); C07C 251/54 (2006.01); C07C 271/34 (2006.01); C07C 317/28 (2006.01); C07C 317/32 (2006.01); C07C 321/16 (2006.01); C07C 321/22 (2006.01); C07C 321/28 (2006.01); C07D 213/32 (2006.01); C07D 213/69 (2006.01); C07D 213/70 (2006.01); C07D 215/12 (2006.01); C07D 217/24 (2006.01); C07D 231/12 (2006.01); C07D 231/20 (2006.01); C07D 239/26 (2006.01); C07D 241/12 (2006.01); C07D 277/24 (2006.01); C07D 305/08 (2006.01); C07D 309/06 (2006.01); C07D 309/12 (2006.01); C07D 311/58 (2006.01); C07D 311/76 (2006.01); C07D 319/20 (2006.01); C07D 333/16 (2006.01); C07F 9/117 (2006.01); C07F 9/62 (2006.01); C07F 9/6503 (2006.01); C07F 9/6509 (2006.01); C07F 9/655 (2006.01); C07F 9/6553 (2006.01); A61K 31/137 (2006.01); A61K 31/15 (2006.01); A61K 31/165 (2006.01); A61K 31/166 (2006.01); A61K 31/17 (2006.01); A61K 31/222 (2006.01); A61K 31/24 (2006.01); A61K 31/27 (2006.01); A61K 31/337 (2006.01); A61K 31/351 (2006.01); A61K 31/352 (2006.01); A61K 31/381 (2006.01); A61K 31/415 (2006.01); A61K 31/4174 (2006.01); A61K 31/426 (2006.01); A61K 31/44 (2006.01); A61K 31/4402 (2006.01); A61K 31/4406 (2006.01); A61K 31/4409 (2006.01); A61K 31/47 (2006.01); A61K 31/4965 (2006.01); A61K 31/505 (2006.01); A61K 31/661 (2006.01)
CPC A61K 31/695 (2013.01) [A61K 31/135 (2013.01); A61K 31/137 (2013.01); A61K 31/15 (2013.01); A61K 31/165 (2013.01); A61K 31/166 (2013.01); A61K 31/17 (2013.01); A61K 31/222 (2013.01); A61K 31/24 (2013.01); A61K 31/27 (2013.01); A61K 31/337 (2013.01); A61K 31/351 (2013.01); A61K 31/352 (2013.01); A61K 31/381 (2013.01); A61K 31/415 (2013.01); A61K 31/4174 (2013.01); A61K 31/426 (2013.01); A61K 31/44 (2013.01); A61K 31/4402 (2013.01); A61K 31/4406 (2013.01); A61K 31/4409 (2013.01); A61K 31/47 (2013.01); A61K 31/4965 (2013.01); A61K 31/505 (2013.01); A61K 31/661 (2013.01); C07C 215/42 (2013.01); C07C 217/52 (2013.01); C07C 217/58 (2013.01); C07C 217/74 (2013.01); C07C 219/24 (2013.01); C07C 233/41 (2013.01); C07C 233/65 (2013.01); C07C 235/46 (2013.01); C07C 251/38 (2013.01); C07C 251/42 (2013.01); C07C 251/44 (2013.01); C07C 251/50 (2013.01); C07C 251/52 (2013.01); C07C 251/54 (2013.01); C07C 271/34 (2013.01); C07C 275/26 (2013.01); C07C 317/28 (2013.01); C07C 317/32 (2013.01); C07C 321/16 (2013.01); C07C 321/22 (2013.01); C07C 321/28 (2013.01); C07C 323/25 (2013.01); C07C 323/29 (2013.01); C07D 209/46 (2013.01); C07D 213/32 (2013.01); C07D 213/38 (2013.01); C07D 213/69 (2013.01); C07D 213/70 (2013.01); C07D 215/12 (2013.01); C07D 215/14 (2013.01); C07D 217/24 (2013.01); C07D 231/12 (2013.01); C07D 231/20 (2013.01); C07D 239/26 (2013.01); C07D 241/04 (2013.01); C07D 241/12 (2013.01); C07D 277/24 (2013.01); C07D 305/08 (2013.01); C07D 309/06 (2013.01); C07D 309/12 (2013.01); C07D 311/58 (2013.01); C07D 311/76 (2013.01); C07D 319/20 (2013.01); C07D 333/16 (2013.01); C07F 7/08 (2013.01); C07F 7/081 (2013.01); C07F 9/091 (2013.01); C07F 9/117 (2013.01); C07F 9/5442 (2013.01); C07F 9/5728 (2013.01); C07F 9/62 (2013.01); C07F 9/65031 (2013.01); C07F 9/65522 (2013.01); C07F 9/650952 (2013.01); C07F 9/655345 (2013.01); C07B 2200/05 (2013.01); C07C 2601/02 (2017.05); C07C 2601/04 (2017.05); C07C 2601/08 (2017.05); C07C 2602/10 (2017.05); C07C 2603/74 (2017.05)] 5 Claims
 
1. A compound of Formula (IV):

OG Complex Work Unit Chemistry
or a salt thereof, wherein:
R1 is —OH or —OP(O)(OH)2;
R2a is —C(O)(CH2)0-4C(Rx)3;
each Rx is independently H;
and
each Rb is independently H.