US 11,701,358 B2
Methods of inhibiting serum glucocorticoid induced kinase 1 (SGKI) as a treatment for salt and water balance diseases
Bonnie L. Blazer-Yost, Indianapolis, IN (US); Nicola Perrotti, Catanzaro (IT); and Silvia Schenone, Castelnuovo Berardenga (IT)
Assigned to Indiana University Research and Technology Corporation, Indianapolis, IN (US)
Appl. No. 16/487,239
Filed by Indiana University Research and Technology Corporation, Indianapolis, IN (US); Universita Magna Graecia (UMG) at Catanzaro, Catanzaro (IT); and Lead Discovery Siena, Siena SI (IT)
PCT Filed Feb. 14, 2018, PCT No. PCT/US2018/018177
§ 371(c)(1), (2) Date Aug. 20, 2019,
PCT Pub. No. WO2018/156401, PCT Pub. Date Aug. 30, 2018.
Claims priority of provisional application 62/463,157, filed on Feb. 24, 2017.
Prior Publication US 2019/0365765 A1, Dec. 5, 2019
Int. Cl. A61K 31/519 (2006.01); A61K 9/00 (2006.01); A61K 31/11 (2006.01); A61K 31/145 (2006.01); A61K 31/4439 (2006.01); A61K 31/4709 (2006.01); A61K 31/4965 (2006.01); A61K 31/5377 (2006.01); A61K 31/55 (2006.01); A61K 31/585 (2006.01)
CPC A61K 31/519 (2013.01) [A61K 9/0053 (2013.01); A61K 31/11 (2013.01); A61K 31/145 (2013.01); A61K 31/4439 (2013.01); A61K 31/4709 (2013.01); A61K 31/4965 (2013.01); A61K 31/5377 (2013.01); A61K 31/55 (2013.01); A61K 31/585 (2013.01)] 9 Claims
 
1. A method to reduce a volume of cerebrospinal fluid (CSF) in a ventricular system of a brain in a mammal having communicating hydrocephalus, the method comprising:
administering to the mammal a SI113, or a pharmaceutically-acceptable salt thereof;
inhibiting transepithelial ion transport from the choroid plexus to the ventricular system of the brain; and,
reducing the volume of CSF in the ventricular system of the brain in the hydrocephalic mammal.