CPC A61K 31/519 (2013.01) [A61K 9/0053 (2013.01); A61K 31/11 (2013.01); A61K 31/145 (2013.01); A61K 31/4439 (2013.01); A61K 31/4709 (2013.01); A61K 31/4965 (2013.01); A61K 31/5377 (2013.01); A61K 31/55 (2013.01); A61K 31/585 (2013.01)] | 9 Claims |
1. A method to reduce a volume of cerebrospinal fluid (CSF) in a ventricular system of a brain in a mammal having communicating hydrocephalus, the method comprising:
administering to the mammal a SI113, or a pharmaceutically-acceptable salt thereof;
inhibiting transepithelial ion transport from the choroid plexus to the ventricular system of the brain; and,
reducing the volume of CSF in the ventricular system of the brain in the hydrocephalic mammal.
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