US 11,701,333 B2
Antibacterial compounds
Jennifer Hiscock, Canterbury (GB); Daniel Mulvihill, Canterbury (GB); and Gary Robinson, Canterbury (GB)
Assigned to KENT INNOVATION & ENTERPRISE, Canterbury (GB)
Appl. No. 16/632,194
Filed by KENT INNOVATION & ENTERPRISE, Canterbury (GB)
PCT Filed Jul. 18, 2018, PCT No. PCT/EP2018/069568
§ 371(c)(1), (2) Date Jan. 17, 2020,
PCT Pub. No. WO2019/016293, PCT Pub. Date Jan. 24, 2019.
Claims priority of application No. 1711555 (GB), filed on Jul. 18, 2017.
Prior Publication US 2021/0128501 A1, May 6, 2021
Int. Cl. A61K 31/17 (2006.01); A61P 31/04 (2006.01); A01N 47/30 (2006.01); A01N 47/36 (2006.01); A01N 47/44 (2006.01); A01N 57/22 (2006.01); A61K 31/155 (2006.01); A61K 31/428 (2006.01); A61K 31/513 (2006.01); A61K 31/662 (2006.01); A61K 45/06 (2006.01)
CPC A61K 31/17 (2013.01) [A01N 47/30 (2013.01); A01N 47/36 (2013.01); A01N 47/44 (2013.01); A01N 57/22 (2013.01); A61K 31/155 (2013.01); A61K 31/428 (2013.01); A61K 31/513 (2013.01); A61K 31/662 (2013.01); A61K 45/06 (2013.01); A61P 31/04 (2018.01)] 18 Claims
 
1. A method of reducing the number or preventing the multiplication of live Gram-negative and/or Gram-positive bacteria on a surface comprising a step of applying to the surface a solution of a compound of formula (I):

OG Complex Work Unit Chemistry
wherein
Ar is

OG Complex Work Unit Chemistry
X is O, S, or NH;
A is such that Am− is an oxygen-containing anionic group;
Y is such that Yn+ is an inorganic or organic cation or proton (Ft);
G is N or CH;
E is S, O or NH;
R6 and R7 are independently selected for each value of q from hydrogen or a straight-chain, branched chain or cyclic or polycyclic C1 to C10 hydrocarbyl group;
R1-R5, R8 and R9 are selected from hydrogen, —CF3, —CCl3, —NHR10, —NR210, —OR10, —OH, —NHC(O)R10, —OCOR10, —COH, —COR10, COOH, COOR10, CONH2, —CN, —SO3H NO2, —OMe, —NH2, halogen, CONHR10, —C(O)NH(CH2)SO3—, a straight-chain, branched chain or cyclic or polycyclic C1 to C10 hydrocarbyl group, a cyclic or polycyclic group comprising 1 or more heteroatoms selected from O, N and S and optionally further substituted with a straight-chain or branched chain C1-C8 hydrocarbyl group, or a nucleobase-containing group

OG Complex Work Unit Chemistry
wherein, optionally, at least one of the pairs of groups R1/R2, R2/R3, R3/R4 and R4/R5 is such that the pair(s) form a cyclic or polycyclic moiety, optionally comprising one or more heterotatoms, fused to the benzene ring in Ar1, or the pair R8/R9 forms a cyclic or polycyclic moiety fused to the ring substituted with G and E in Ar2 wherein the cyclic or polycyclic moiety is optionally substituted with a straight-chain or branched chain C1-C8 hydrocarbyl group;
R10 is a straight-chain, branched chain or cyclic or polycyclic C1 to C10 hydrocarbyl group;
q is an integer from 1-10; and
m and n are each independently an integer from 1-3.