	US 11,701,329 B2
	Treatment method for colon cancer
Ayhan Bozkurt, Dammam (SA); Seyda Tugba Gunday Anil, Dammam (SA); Firdos Alam Khan, Dammam (SA); and Sultan Akhtar, Dammam (SA)
Assigned to Imam Abdulrahman Bin Faisal University, Dammam (SA)
Filed by Imam Abdulrahman Bin Faisal University, Dammam (SA)
Filed on Sep. 30, 2022, as Appl. No. 17/956,887.
Application 17/956,887 is a continuation of application No. 16/403,049, filed on May 3, 2019, granted, now 11,491,110.
Prior Publication US 2023/0044963 A1, Feb. 9, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/16 (2006.01); A61K 33/26 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); A61K 33/00 (2006.01)

CPC A61K 9/16 (2013.01) [A61K 9/1682 (2013.01); A61K 33/00 (2013.01); A61K 33/26 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01)]

5 Claims

1. A treatment method for colon cancer, comprising:

administering to a subject in need of treatment for colon cancer an aqueous composition comprising Fe₃O₄-hollow silica spheres (“Fe-HSS”),

wherein the aqueous composition is administered in an amount sufficient to induce nuclear condensation, augmentation, and disintegration of cells of the cancer,

wherein the Fe-HSS are calcined,

wherein the surfaces of the Fe-HSS comprise no more than 0.05 mol. % phenyl or aryl groups, relative to an average uncalcined Fe-HSS,

wherein Fe-HSS have a hollow core space containing plural individual particles of Fe₃O₄having an average diameter in a range of from 9.5 nm to 21.3 nm and the Fe₃O₄has a polycrystalline spinel structure,

wherein the hollow silica spheres of the Fe₃O₄-hollow silica spheres have a core-shell structure with shells larger in thickness than cores, and the hollow silica spheres have an average diameter in a range of from 415 to 615 nm,

wherein the Fe-HSS have an average shell thickness in a range of from 150 to 210 nm, and

wherein the particles of Fe₃O₄are present a range of from 0.1 to 10 wt % of a combined weight of the HSS and Fe₃O₄in the Fe-HSS.