US 11,701,253 B2
Systems, devices and methods including galvanic and caloric vestibular stimulation
Robert D. Black, Chapel Hill, NC (US); Lanty L. Smith, Durham, NC (US); and Lesco L. Rogers, Raleigh, NC (US)
Assigned to Scion NeuroStim, Inc., Durham, NC (US)
Filed by Scion NeuroStim, Inc., Durham, NC (US)
Filed on May 10, 2021, as Appl. No. 17/315,542.
Application 17/315,542 is a continuation of application No. 15/914,516, filed on Mar. 7, 2018, granted, now 11,026,835.
Application 15/914,516 is a continuation in part of application No. PCT/US2016/049824, filed on Sep. 1, 2016.
Application PCT/US2016/049824 is a continuation in part of application No. PCT/US2016/049827, filed on Sep. 1, 2016.
Application PCT/US2016/049827 is a continuation in part of application No. PCT/US2016/049836, filed on Sep. 1, 2016.
Claims priority of provisional application 62/322,985, filed on Apr. 15, 2016.
Claims priority of provisional application 62/214,474, filed on Sep. 4, 2015.
Prior Publication US 2021/0259879 A1, Aug. 26, 2021
Int. Cl. A61F 7/12 (2006.01); A61N 1/04 (2006.01); A61N 1/36 (2006.01); A61B 6/03 (2006.01); A61N 1/05 (2006.01); A61F 7/00 (2006.01); A61M 21/02 (2006.01); H04R 1/10 (2006.01); A61M 21/00 (2006.01); A61N 1/32 (2006.01)
CPC A61F 7/12 (2013.01) [A61B 6/037 (2013.01); A61F 7/007 (2013.01); A61M 21/02 (2013.01); A61N 1/0456 (2013.01); A61N 1/0484 (2013.01); A61N 1/0526 (2013.01); A61N 1/36021 (2013.01); A61N 1/36025 (2013.01); A61N 1/36028 (2013.01); A61N 1/36031 (2017.08); A61N 1/36034 (2017.08); H04R 1/1016 (2013.01); H04R 1/1091 (2013.01); A61F 2007/0005 (2013.01); A61F 2007/0075 (2013.01); A61F 2007/0093 (2013.01); A61F 2007/126 (2013.01); A61M 2021/0027 (2013.01); A61M 2021/0072 (2013.01); A61M 2021/0077 (2013.01); A61M 2205/054 (2013.01); A61M 2210/0662 (2013.01); A61N 1/327 (2013.01); H04R 1/10 (2013.01); H04R 2460/13 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A vestibular neurostimulation device, comprising:
first and second electrodes;
first and second thermoelectric devices thermally coupled, respectively, to first and second earpieces configured to be insertable into respective ear canals of a patient; and
a controller comprising a waveform generator that is configured to deliver a modulated electric signal to the patient through galvanic vestibular stimulation (GVS) using the first and second electrodes and to deliver a time varying thermal waveform to the patient through caloric vestibular stimulation (CVS) using the first and second earpieces simultaneous with the delivery of the modulated electrical signal through GVS,
wherein the CVS and/or GVS is configured to increase a passage of insulin-like growth factor 1 (IGF-1) through a blood-brain-barrier.