	US 11,701,175 B2
	System and method for vascular tree generation using patient-specific structural and functional data, and joint prior information
Ying Bai, Belmont, CA (US); Michiel Schaap, Redwood City, CA (US); Charles A. Taylor, Atherton, CA (US); and Leo Grady, Millbrae, CA (US)
Assigned to HeartFlow, Inc., Mountain View, CA (US)
Filed by HeartFlow, Inc., Redwood City, CA (US)
Filed on Aug. 14, 2019, as Appl. No. 16/540,440.
Application 16/540,440 is a continuation of application No. 15/094,626, filed on Apr. 8, 2016, granted, now 10,420,610.
Claims priority of provisional application 62/145,714, filed on Apr. 10, 2015.
Prior Publication US 2019/0365470 A1, Dec. 5, 2019
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 34/10 (2016.01); G16H 50/50 (2018.01); A61B 34/00 (2016.01); G06T 7/187 (2017.01); G06T 7/11 (2017.01); A61B 6/00 (2006.01); G06T 7/00 (2017.01); A61B 6/03 (2006.01)

CPC A61B 34/10 (2016.02) [A61B 6/503 (2013.01); A61B 6/504 (2013.01); A61B 6/507 (2013.01); A61B 34/00 (2016.02); G06T 7/0014 (2013.01); G06T 7/11 (2017.01); G06T 7/187 (2017.01); G16H 50/50 (2018.01); A61B 6/032 (2013.01); A61B 2034/105 (2016.02); G06T 2207/10072 (2013.01); G06T 2207/10081 (2013.01); G06T 2207/10088 (2013.01); G06T 2207/10104 (2013.01); G06T 2207/10108 (2013.01); G06T 2207/30101 (2013.01); G06T 2207/30104 (2013.01)]

20 Claims

1. A computer implemented method for generating a vascular tree model, the method comprising:

receiving joint prior information associated with a patient-specific vascular model of a patient's anatomy and a patient-specific target tissue model, the joint prior information including geometrical, physiological, and/or topological priors electronically learned from intensity variation data in one or more patient-specific images of the patient's anatomy;

determining, using a processor, one or more associations between a vascular network of the patient-specific vascular model and one or more perfusion characteristics of a target tissue of the target tissue model using the joint prior information;

generating, using a processor, a vascular tree model including a microvascular model that extends to perfusion regions in the target tissue, using the determined associations between the vascular network of the patient-specific vascular model and the perfusion characteristics of the target tissue;

calculating an estimation of supplied blood to the target tissue according to the generated vascular tree model; and

providing a diagnosis of cardiovascular disease according to the estimation of supplied blood to the target tissue.