US 11,701,172 B2
Device and method for treating cardiac disorders by modulating autonomic response
Samuel J. Asirvatham, Rochester, MN (US); and Mark B. Knudson, Shoreview, MN (US)
Assigned to Mayo Foundation for Medical Education and Research, Rochester, MN (US)
Filed by Mayo Foundation for Medical Education and Research, Rochester, MN (US)
Filed on Mar. 31, 2021, as Appl. No. 17/219,120.
Application 17/219,120 is a continuation of application No. 16/196,473, filed on Nov. 20, 2018, granted, now 10,973,573.
Application 16/196,473 is a continuation of application No. 15/184,379, filed on Jun. 16, 2016, abandoned.
Application 15/184,379 is a continuation of application No. 13/515,630, granted, now 9,392,971, issued on Jul. 19, 2016, previously published as PCT/US2010/058950, filed on Dec. 3, 2010.
Claims priority of provisional application 61/286,303, filed on Dec. 14, 2009.
Prior Publication US 2021/0212761 A1, Jul. 15, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 18/18 (2006.01); A61B 18/14 (2006.01); A61N 1/20 (2006.01); A61B 5/0215 (2006.01); A61B 18/02 (2006.01); A61M 25/00 (2006.01); A61M 25/04 (2006.01); A61M 25/10 (2013.01); A61N 1/05 (2006.01); A61B 5/24 (2021.01); A61B 5/318 (2021.01); A61B 5/00 (2006.01); A61N 1/36 (2006.01); A61B 5/02 (2006.01); A61B 18/00 (2006.01); A61N 1/06 (2006.01)
CPC A61B 18/1492 (2013.01) [A61B 5/0215 (2013.01); A61B 5/24 (2021.01); A61B 5/318 (2021.01); A61B 5/4035 (2013.01); A61B 18/02 (2013.01); A61M 25/007 (2013.01); A61M 25/04 (2013.01); A61M 25/10 (2013.01); A61N 1/0587 (2013.01); A61N 1/20 (2013.01); A61N 1/36114 (2013.01); A61B 5/02 (2013.01); A61B 2018/0022 (2013.01); A61B 2018/00083 (2013.01); A61B 2018/00214 (2013.01); A61B 2018/00351 (2013.01); A61B 2018/00434 (2013.01); A61B 2018/00577 (2013.01); A61B 2018/00839 (2013.01); A61B 2018/00994 (2013.01); A61B 2218/002 (2013.01); A61M 2025/105 (2013.01); A61N 1/06 (2013.01)] 15 Claims
OG exemplary drawing
 
1. A method for treating a cardiac disorder, the method comprising:
advancing a sheath through a pericardium to position a distal end portion of the sheath in a pericardial space defined between an epicardial surface and the pericardium;
advancing a catheter through the sheath to position a distal end portion of the catheter in the pericardial space, the distal end portion of the catheter including multiple electrodes and defining multiple infusion ports; and
placing the multiple electrodes in direct contact with the epicardial surface and delivering to the epicardial surface:
pulsed electrical field (PEF) energy from the multiple electrodes; and
fluid from the multiple infusion ports, wherein the fluid disperses the PEF energy to broaden coverage of the PEF energy delivered to the epicardial surface,
wherein the PEF energy delivered to the epicardial surface modulates autonomic nervous system ganglia to treat the cardiac disorder.