US 11,692,996 B2
Device for detection of cellular stress
Ji-Xin Cheng, Newton, MA (US); Junjie Li, Arlington, MA (US); Yuying Tan, Allston, MA (US); Daniela Matei, Chicago, IL (US); and Guangyuan Zhao, Chicago, IL (US)
Assigned to Trustees of Boston University, Boston, MA (US); and Northwestern University, Evanston, IL (US)
Filed by Trustees of Boston University, Boston, MA (US); and Northwestern University, Evanston, IL (US)
Filed on Jun. 13, 2022, as Appl. No. 17/839,080.
Claims priority of provisional application 63/210,286, filed on Jun. 14, 2021.
Prior Publication US 2023/0039153 A1, Feb. 9, 2023
Int. Cl. G01J 3/44 (2006.01); G01N 33/49 (2006.01); G01N 27/416 (2006.01); G01Q 60/60 (2010.01); G16H 20/10 (2018.01); G16H 50/30 (2018.01); G01N 33/487 (2006.01); G01N 27/30 (2006.01); G01N 21/65 (2006.01)
CPC G01N 33/492 (2013.01) [G01N 27/30 (2013.01); G01N 27/416 (2013.01); G01N 33/48735 (2013.01); G01Q 60/60 (2013.01); G16H 20/10 (2018.01); G16H 50/30 (2018.01); G01N 21/65 (2013.01); G01N 2800/52 (2013.01)] 20 Claims
OG exemplary drawing
 
1. An assay for determining resistance in a target cell or tissue to a therapy associated with cellular stress, comprising,
measuring with chemical microscopy a functional metabolic change in the target cell or tissue, and
determining a metabolic index of resistance in the target cell or tissue to the therapy.