	US 11,692,192 B2
	Anti-microbial and UV-protective extracts and methods of making and using thereof
Raul Cuero Rengifo, Cypress, TX (US); and Juliana Londoño Murillo, Manizales (CO)
Assigned to BIOCAPITAL HOLDINGS, LLC, Houston, TX (US)
Appl. No. 16/971,347
Filed by BIOCAPITAL HOLDINGS, LLC, Houston, TX (US)
PCT Filed Feb. 22, 2019, PCT No. PCT/US2019/019075 § 371(c)(1), (2) Date Aug. 20, 2020, PCT Pub. No. WO2019/165163, PCT Pub. Date Aug. 29, 2019.
Claims priority of provisional application 62/754,291, filed on Nov. 1, 2018.
Claims priority of provisional application 62/634,251, filed on Feb. 23, 2018.
Prior Publication US 2021/0017525 A1, Jan. 21, 2021
Int. Cl. C12N 15/00 (2006.01); C12N 15/52 (2006.01); A61K 8/9728 (2017.01); A01N 63/50 (2020.01); C05F 11/00 (2006.01); C12N 15/62 (2006.01); C09D 5/16 (2006.01); C09D 5/32 (2006.01); C12N 9/02 (2006.01); C12N 9/04 (2006.01); C12N 9/20 (2006.01); C12N 15/81 (2006.01); C08G 18/32 (2006.01); C08G 18/76 (2006.01); A61K 8/99 (2017.01); C08G 101/00 (2006.01); C12N 15/70 (2006.01); C07K 14/405 (2006.01); C12N 9/64 (2006.01)

CPC C12N 15/52 (2013.01) [A01N 63/50 (2020.01); A61K 8/9728 (2017.08); A61K 8/99 (2013.01); C05F 11/00 (2013.01); C08G 18/3218 (2013.01); C08G 18/7671 (2013.01); C09D 5/1637 (2013.01); C09D 5/32 (2013.01); C12N 9/0006 (2013.01); C12N 9/0091 (2013.01); C12N 9/20 (2013.01); C12N 15/62 (2013.01); C12N 15/81 (2013.01); C12Y 101/01001 (2013.01); C07K 14/405 (2013.01); C07K 2319/00 (2013.01); C08G 2101/00 (2013.01); C12N 9/641 (2013.01); C12N 15/70 (2013.01)]

26 Claims

1. A biological device comprising microbial host cells transformed with a vector, wherein the vector comprises a DNA construct comprising the following genetic components:

(a) a gene having the nucleic acid sequence of SEQ ID NO. 1 or at least 90% homology thereto that encodes a zinc-related protein/oxidase,

(b) a gene having the nucleic acid sequence of SEQ ID NO. 2 or at least 90% homology thereto that encodes a silicatein,

(c) a gene having the nucleic acid sequence of SEQ ID NO. 3 or at least 90% homology thereto that encodes a silaffin, and

(d) a gene having the nucleic acid sequence of SEQ ID NO. 4 or at least 90% homology thereto that encodes an alcohol dehydrogenase II.