CPC C07K 14/045 (2013.01) [A61K 35/33 (2013.01); A61K 39/0011 (2013.01); A61K 39/12 (2013.01); A61K 39/39 (2013.01); C12N 15/85 (2013.01); C12N 15/86 (2013.01); A61K 39/21 (2013.01); A61K 2039/5254 (2013.01); A61K 2039/5256 (2013.01); A61K 2039/572 (2013.01); A61P 35/00 (2018.01); C07K 14/161 (2013.01); C12N 2710/16143 (2013.01); C12N 2740/15034 (2013.01); C12N 2740/16234 (2013.01)] | 30 Claims |
1. A recombinant human cytomegalovirus (HCMV) comprising:
(1) a first nucleic acid encoding at least one heterologous antigen;
(2) an inactivating mutation in the UL45 gene; and
(3) active US2, US3, US6, US7, UL97, and UL131A genes;
wherein the recombinant HCMV is a genetically modified TR strain of HCMV; and the recombinant HCMV is ganciclovir-sensitive.
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