CPC C07H 1/06 (2013.01) [A61K 31/713 (2013.01)] | 22 Claims |
1. A method for analysis or purification of a mixture comprising at least two harmonized RNA species, the method comprising:
a) obtaining the coding sequences for at least two RNA species, said at least two RNA species each having a length of 800 to 20,000 nucleotides wherein the sequence of at least one RNA species is adapted by altering the number of A and/or U nucleotides in the RNA sequence with respect to the number of A and/or U nucleotides in the original RNA sequence, said coding sequences of the at least two RNA species having a harmonized number of encoded A and U nucleotides that is no more than 50 different from each other;
b) synthesizing the at least two RNA species to produce at least two harmonized RNA species; and
c) analysing and/or purifying a mixture of said at least two harmonized RNA species by chromatography.
|