CPC A61K 31/702 (2013.01) [A23L 33/10 (2016.08); A23L 33/12 (2016.08); A23L 33/135 (2016.08); A23L 33/19 (2016.08); A23L 33/30 (2016.08); A23L 33/40 (2016.08); A61K 9/107 (2013.01); A61K 31/716 (2013.01); A61K 31/733 (2013.01); A61K 35/20 (2013.01); A61K 35/744 (2013.01); A61K 35/745 (2013.01); A61K 35/747 (2013.01); A61K 36/48 (2013.01); A61K 38/018 (2013.01); A61K 45/06 (2013.01); A23V 2002/00 (2013.01); A61K 2035/11 (2013.01); A61K 2035/115 (2013.01)] | 16 Claims |
1. A shelf stable synthetic formula for improving the feeding tolerance of an infant, toddler, or child, the synthetic formula comprising:
from about 0.04 mg/mL to about 20 mg/mL of a human milk oligosaccharide blend consisting of 2′-fucosyllactose, 3-fucosyllactose, 3′-sialyllactose, 6′-sialyllactose, and at least one of lacto-N-tetraose and lacto-N-neotetraose, wherein the oligosaccharide blend comprises 2′-fucosyllactose, in a concentration of from 0.01 mg/mL to 10 mg/mL, and 6′-sialyllactose, in a concentration of from 0.01 to 10 mg/mL;
from about 0.001 g/L to about 1 g/L of a long chain polyunsaturated fatty acid component comprising docosahexaenoic acid and arachidonic acid, wherein the ratio of docosahexaenoic acid to arachidonic acid is from about 1:4 to about 1:2;
from about 0.001 μg/mL to about 5 μg/mL of a carotenoid component comprising lutein, lycopene, beta-carotene, or a combination thereof;
from about 42 mg/L to about 200 mg/L of a monomeric monophosphate nucleotide component;
wherein from about 7% to about 40% of total calories in the formula are derived from protein, from about 25% to about 50% of total calories in the formula are derived from fat, and from about 35% to about 55% of total calories in the formula are derived from carbohydrates; and
wherein the synthetic formula is shelf stable for at least 3 months.
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