CPC A61K 31/553 (2013.01) [A61K 31/50 (2013.01); A61K 31/501 (2013.01); A61K 31/506 (2013.01); A61K 31/55 (2013.01); A61K 31/551 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); C07D 237/24 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/12 (2013.01); C07D 409/12 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/12 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 491/107 (2013.01); C07D 498/04 (2013.01)] | 24 Claims |
1. A compound of structural Formula I:
or a salt thereof, wherein:
R1 is chosen from alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, (cycloalkyl)alkyl, (heterocycloalkyl)alkyl, (aryl)alkyl, and (heteroaryl)alkyl, any one of which is optionally substituted with one or more R5;
R2 is chosen from H, alkyl, haloalkyl, and (alkoxy)alkyl;
R3 is chosen from H, CN, halo, alkyl, and alkoxy;
or R2 and R3, together with the intervening atoms, combine to form a 5-, 6-, or 7-membered cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
R4a is H;
R4b is chosen from
each R5 is independently chosen from CN, halo, hydroxy, oxo, alkyl, and (alkyl)oxy; and
each R6a is independently chosen from H, CN, halo, hydroxy, oxo, C1-6alkyl, haloC1-6alkyl, C3-7 cycloalkyl, 4- to 11-membered heterocycloalkyl, C6-10aryl, 5- to 10-membered heteroaryl, (C2-6alkenyl)C1-6alkyl, (C2-6alkynyl)C1-6alkyl, (C3-7cycloalkyl)C1-6alkyl, (4- to 11-membered heterocycloalkyl)C1-6alkyl, (C6-10aryl)C1-6alkyl, (5- to 10-membered heteroaryl)C1-6 alkyl, (C1-6 alkyl)oxy, (C3-7cycloalkyl)oxy, (4- to 11-membered heterocycloalkyl)oxy, (C6-10aryl)oxy, and (5- to 10-membered heteroaryl)oxy; and
R6b is chosen from H and C1-6alkyl.
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