US 11,690,823 B2
Pharmaceutical composition
Stuart Corr, Warrington (GB); and Timothy James Noakes, Flintshire (GB)
Assigned to MEXICHEM FLUOR S.A. DE C.V., San Luis Potosi S.L.P. (MX)
Filed by MEXICHEM FLUOR S.A. DE C.V., San Luis Potosi S.L.P. (MX)
Filed on Sep. 7, 2021, as Appl. No. 17/467,778.
Application 17/467,778 is a continuation of application No. 16/582,993, filed on Sep. 25, 2019, granted, now 11,179,366.
Application 16/582,993 is a continuation of application No. 16/334,158, granted, now 10,888,546, issued on Jan. 12, 2021, previously published as PCT/GB2017/052761, filed on Sep. 18, 2017.
Claims priority of application No. 1615917 (GB), filed on Sep. 19, 2016; and application No. 1620519 (GB), filed on Dec. 2, 2016.
Prior Publication US 2021/0401800 A1, Dec. 30, 2021
Int. Cl. A61K 31/137 (2006.01); A61K 31/40 (2006.01); A61K 47/58 (2017.01); A61P 11/00 (2006.01); A61K 9/00 (2006.01); A61K 31/4704 (2006.01); A61K 31/573 (2006.01); A61K 47/10 (2017.01); A61K 47/24 (2006.01); A61K 45/06 (2006.01); A61K 31/56 (2006.01); A61K 47/12 (2006.01); A61K 47/32 (2006.01)
CPC A61K 31/40 (2013.01) [A61K 9/008 (2013.01); A61K 31/4704 (2013.01); A61K 31/56 (2013.01); A61K 31/573 (2013.01); A61K 45/06 (2013.01); A61K 47/10 (2013.01); A61K 47/12 (2013.01); A61K 47/24 (2013.01); A61K 47/32 (2013.01); A61K 47/58 (2017.08); A61P 11/00 (2018.01)] 20 Claims
 
1. A method of improving the stability of a pharmaceutical composition comprising:
adding a propellant component consisting of one or more hydrofluorocarbon and hydrocarbon propellant compounds, where at least 90 wt % of the propellant component is 1,1-difluoroethane (HFA-152a), to the pharmaceutical composition, the pharmaceutical composition comprising a drug component comprising at least one pharmaceutically acceptable salt of glycopyrrolate,
wherein the drug component is the sole drug component in the pharmaceutical composition.